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Science Friday

65 Genomes Expand Our Picture Of Human Genetics

Science Friday

Science Friday and WNYC Studios

Life Sciences, Wnyc, Science, Earth Sciences, Natural Sciences, Friday

4.55.5K Ratings

🗓️ 5 August 2025

⏱️ 18 minutes

🧾️ Download transcript

Summary

Researchers closely examined the genomes of 65 individuals to paint a more complex, and more complete, picture of human genetic diversity.

Transcript

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0:00.0

Hey, it's Ira Flato, and this is Science Friday.

0:07.0

A new look at the human genome, both with more detail and more diversity.

0:12.4

And the point in doing this is to understand how we differ in our sequences, our structures,

0:16.7

and trying to understand how proteins also differ amongst us.

0:24.1

Remember the human genome project?

0:27.0

Well, the initial draft was declared complete back in 2003.

0:32.1

But researchers then realized that one genome doesn't paint a complete picture of the human race. So fast forward

0:39.6

a decade or so, there came the thousand genomes project, an attempt to expand the picture by

0:46.1

sampling people from all over the world with different backgrounds and try to get a fuller look

0:52.6

at how we're the same or how we're different. Writing this

0:56.6

month in a journal Nature, two teams of researchers take another look at some of those thousand genomes,

1:03.1

resequencing, reassembling with more advanced techniques to lessen the number of typos and really

1:09.8

firm up how the pieces of the genome puzzle fit together.

1:13.4

Joining me now to talk about how it's going are my guest, Dr. Christine Beck,

1:17.2

Associate Professor of Genetics and Genome Sciences at the University of Connecticut Health Center

1:22.5

and the Jackson Laboratory. She's in Farmington, Connecticut.

1:26.3

Dr. Glenis Logston, assistant professor of genetics

1:29.6

and core member of the Epigenetics Institute at the University of Pennsylvania in Philly.

1:36.0

And Dr. Adam Philippi, a senior investigator in the Center for Genomics and Data Science Research

1:41.1

at the National Human Genome Research Institute at the NIH in Bethesda,

1:46.9

Maryland. Welcome all of you to Science Friday. Thanks. Thanks, Ira. Great to be here.

1:51.7

Nice to have you all. Dr. Logston, let me start with you. What's the thousand mile view of this paper?

...

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