62 – How hormones change your brain - Dr Jay Jagannathan
The Dr Louise Newson Podcast
Dr Louise Newson
4.7 • 933 Ratings
🗓️ 30 April 2026
⏱️ 29 minutes
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Summary
What if the symptoms women are told are down to stress or hectic lifestyles are actually coming from hormone changes in the brain?
In this episode, Dr Louise Newson is joined by board certified neurosurgeon, Dr Jay Jagannathan, for a fascinating and eye-opening conversation about the role hormones play in brain health.
They explore what’s really happening during times of hormonal change such as perimenopause and menopause, and what’s driving symptoms such as memory problems, low mood and brain fog. Together, they unpack the science behindthese changes, including how hormones influence brain structure, neurotransmitters and inflammation.
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Transcript
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| 0:00.0 | So Jay, I'm very excited for this podcast. |
| 0:04.8 | We're recording it on a Sunday night because you're super busy. |
| 0:07.9 | I'm quite busy. |
| 0:08.9 | But you are a neurosurgeon. |
| 0:11.3 | So you are the creme de la creme of medicine. |
| 0:13.9 | I should be bowing and cursing in front of you. |
| 0:17.0 | Well, thank you for having me. |
| 0:18.2 | I'm a big fan of your podcast. |
| 0:19.3 | And so I think the value you provide, |
| 0:23.3 | you know, particularly for women in a perimenopausal phase. My grandmother passed away of a heart |
| 0:28.4 | attack that went undetected after menopause. Obviously, after menopause. My mom is early, |
| 0:33.4 | developed breast cancer shortly after menopause. I think it's very critical valuable information. |
| 0:39.1 | And I really applaud your work. |
| 0:41.6 | So it's an honor to be here. |
| 0:42.5 | Thank you. |
| 0:43.1 | Well, I always try and think differently about things because I think it gets people thinking |
| 0:48.4 | in different ways. |
| 0:49.3 | And that's what I'm doing about hormones, about menopause. |
| 0:51.7 | But some people listening know that I actually wanted to do |
| 0:55.0 | oncology many years ago. I wanted to do cancer medicine and I only changed my career for |
| 1:00.6 | lifestyle because I've got three children and I wanted to see them grow up. But my father actually |
| 1:06.7 | died of a glioblastoma, so a brain tumor when I was nine. And I remember going to the |
... |
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