601: How to improve GLP-1 levels, naturally | Colleen Cutcliffe, Ph.D.

The mindbodygreen Podcast

mindbodygreen

Alternative Health, Health & Fitness

4.6 • 2.1K Ratings

🗓️ 8 June 2025

⏱️ 39 minutes

🔗️ Recording | iTunes | RSS

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Summary

“You can improve your metabolism simply through your microbiome,” explains Colleen Cutcliffe, Ph.D. Colleen Cutcliffe, Ph.D., biochemist, microbiologist, and the co-founder and CEO of Pendulum Therapeutics, joins us today to dive deep into the science of the gut microbiome, covering everything from the gut-metabolism axis and increasing GLP-1 levels to gut-supporting foods. Plus: - Starting her company, Pendulum (~2:45) - Assessing microbiome health (~6:25) - The gut-metabolism axis (~8:55) - Increasing GLP-1 naturally (~10:00) - What is Akkermansia (~13:00) - How to increase Akkermansia (~16:55) - Microbiome-supporting foods (~18:53) - How to change your microbiome (~24:45) - Environmental factors & the microbiome (~26:20) - Stress & the microbiome (~28:00) - Reset the gut after antibiotics (~28:45) - The future of microbiome science (~31:05) - Fecal transplants (~34:00) - Exciting new science (~35:55) Referenced in the episode: - Follow Colleen Cutcliffe on Instagram (@drcolleencutcliffe) - Check out her company (https://pendulumlife.com/) - Learn more about their research (https://pendulumlife.com/pages/research-clinical-trials#nav-clinical-trial) - Research on microbiome diversity & pet ownership (https://pmc.ncbi.nlm.nih.gov/articles/PMC7058978/) - Research on Akkermansia & response to cancer immunotherapy This episode is made in partnership with Pendulum’s Akkermansia. Made with a live strain of Akkermansia muciniphila, this supplement can improve gut health and digestion, reduce food cravings, and may even help stimulate GLP-1 production.*† Learn more at pendulumlife.com/MBG, and get 20% off all Pendulum product subscriptions for first orders. Discount applied at checkout. We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. †Based on pre-clinical studies. Not intended for weight loss. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	Welcome to the My Buddy Green podcast. I'm Jason Wachib, founder and co-CEO of My Buddy Green, and your host.
0:07.2	This episode of the MBG podcast was made in partnership with Pendulum. If you care about gut health,
0:12.0	you need to know about acrimancia. Since its discovery in 2004, over 4,500 papers have been
0:18.1	published on the strain, finding that it's essential for keeping a strong
0:21.5	gut lining, supporting metabolism, improving digestive regularity, and maintaining healthy weight.
0:26.7	But here's the catch. To date, it has not been found in food. The only place it occurs naturally
0:31.5	is breast milk. Thanks to an innovative delivery system, Pendulum is the first company in the
0:36.3	market to offer live acrimancia as a daily probiotic. Learn more, Pendulum is the first company in the market to offer live acrimancia
0:38.5	as a daily probiotic. Learn more at pendulumlife.com backslash MBG and get 20% off all Pendulum product
0:46.6	subscriptions on first orders. Discount apply to checkout. That's P-E-N-D-U-L-U-M-I-E dot com slash MBG.
0:57.3	Learn more at pendulumlife.com slash MBG and get 20% off all pendulum product subscriptions on first orders.
1:04.6	Discount apply to checkout. That's P-E-L-U-M-L-M-I-E dot com slash M-B-G.
1:17.1	Fatigue, blood sugar spikes, weight gain.
1:19.5	These symptoms may all trace back to one surprising source, your gut.
1:23.6	In today's show, we're diving into the science of the microbiome with Dr. Colleen Cutliff,
1:27.8	a biochemist, microbiologist, and the co-founder of pendulum therapeutics, accompanied at the forefront
1:33.2	of microbiome science. With a PhD from Johns Hopkins and years of experience in biotech,
1:38.5	Colleen blends scientific expertise with a deeply personal mission to help people, starting with her
1:43.4	own daughter, heal from the long-term impacts of antibiotic use and gut imbalance.
1:48.0	In our conversation, we unpack how a healthy microbiome supports everything from blood sugar regulation to energy levels, and why disruptions to the system can lead to cravings, chronic illness, and even food sensitivities.
1:58.7	We'll also explore how certain microbes can naturally
2:01.3	stimulate GLP1, the same hormone mimicked by today's popular weight loss drugs, and what to look
	...

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