#60 How to Reverse Ageing (Part 4 of 4). The Future of Longevity Research with Professor David Sinclair
The Doctor's Kitchen Podcast
Dr Rupy Aujla
4.7 • 2.7K Ratings
🗓️ 15 July 2020
⏱️ 59 minutes
🧾️ Download transcript
Summary
My guest on the show today is David A. Sinclair, Ph.D, a tenured Professor of Genetics at Harvard Medical School, he is best known for his work on genes and small molecules that delay ageing, including the Sirtuins, NAD precursors, Resveratrol and other epigenetic modifiers.
He has received many honours including a feature on TIME magazine’s list of the “100 most influential people in the world” and this podcast episode about how to treat and reverse ageing will give you a glimpse into why he is so deserving.
On the show we talk about:
- The hallmarks of ageing and why to distinguish it as a disease
- Instead of trying to tackle each one of the 8 central tenants of ageing, how Prof is looking at the epigenome
- Sirtuins and their role in ageing, DNA repair and gene expression
- AMPK, MTor, Sirtuins as regulators of lifespan and defence pathways
- Methods of fighting ageing and activating the body’s natural defence systems
- Energy restriction, aerobic exercise, sauna and cold shock therapy
- energy restriction, exercise triggering hypoxia, sauna, cold shock therapy,
- NAD and NAD precursors, Metformin, rapamycin and resveratrol as molecules that can improve ageing
- Why we need to treat ageing like a disease, which forms the foundation of multiple diseases. If we cure ageing, we cure a lot.
- The ethical considerations of increasing lifespan
Do check out David’s work and his latest book - Lifespan - Why We Age and Why We Don’t Have To.
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Transcript
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| 0:00.0 | And then the question you can ask yourself is, if you were not to age, would you get sick? |
| 0:11.8 | Would you get diseases? |
| 0:12.8 | And I'm arguing that you wouldn't. |
| 0:15.0 | Now bad stuff can still happen. |
| 0:16.8 | We can have mutations that cause disease and cancer is one of those. |
| 0:20.8 | But I think it's important to realize that our bodies are capable of great healing. |
| 0:27.0 | The capable of killing cancer cells on their own through the immune system. |
| 0:31.1 | And that the breakdown of those processes in large part is the reason why we get sick. |
| 0:39.8 | Welcome to the Docksyskitchen podcast, the show about food, lifestyle, medicine and how |
| 0:44.8 | to improve your health today. |
| 0:47.2 | My name is Dr. Rupi. |
| 0:48.2 | I'm a medical doctor. |
| 0:50.1 | I also study nutrition and I'm a firm believer in the power of food and lifestyle as medicine. |
| 0:57.3 | Join me on this podcast where we explore multiple determinants of what allows you to live |
| 1:03.4 | your best life. |
| 1:05.2 | And remember, you can sign up to thedocksyskitchen.com for the newsletter where we give weekly recipes, |
| 1:11.6 | plus tips and hacks on how to improve your lifestyle today. |
| 1:16.7 | This is the final episode of our four-part series on how to reverse aging. |
| 1:22.0 | Today's episode is Treating Aging as a disease with Professor David Sinclair. |
| 1:28.4 | My guest today is a world renowned professor. |
| 1:31.5 | His name's one of Time Magazine's most influential people on the planet. |
| 1:36.3 | His attendee professor of genetics at Harvard Medical School. |
... |
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