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Sigma Nutrition Radio

#537: Appetite Regulation, Metabolic Compensation and More – Stephan Guyenet, PhD

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 1 October 2024

⏱️ 64 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

This is an “ask me anything” (AMA) episode with Dr. Stephan Guyenet, an expert in obesity neuroscience and eating behavior. This episode was originally published on Sigma Nutrition Premium. If you’re interested in subscribing to Sigma Nutrition Premium, then check all the details here.

Questions Answered:

  1. [04.27] If we surgically remove adipose tissue, do leptin levels suddenly drop? How would this impact hunger over time?
  2. [06.56] How does chronic energy restriction (or following a crash diet) affect long-term appetite regulation?
  3. [13.21] How do anorexia and pronounced obesity defy the rules of metabolic compensation?
  4. [24.12] Why do some SDRIs (serotonin–dopamine reuptake inhibitors) reduce hunger/appetite?
  5. [28.02] Can an algorithm really decipher someone’s “ideal weight?
  6. [33.08] Could the “brain microbiome” impact appetite regulation and/or obesity?
  7. [35.34] In our current environment, are the only efficacious interventions drugs and bariatric surgery?
  8. [46.01] What should we make of claims by Gary Taubes about insulinogenic foods?
  9. [52.37] Is there a maximum duration someone should spend in fat loss (or weight gain) phases?
  10. [53.43] Why do some people struggle to gain weight?

Links:

Transcript

Click on a timestamp to play from that location

0:00.0

Hello and welcome to Sigmat Nutrition Radio. This is episode 537 of the podcast. My name is Danny Lennon and you are very welcome to the show.

0:24.7

Today I'm going to be bringing you an episode that was originally published on our premium

0:30.7

feed of the podcast for Sigma Nutrition Premium a bit over two years ago now when we did one of

0:36.2

our special Ask Me Anything or Q&A episodes

0:39.5

with an expert.

0:41.3

And I had the pleasure of putting our premium subscribers questions directly to Dr.

0:47.3

Stefan Giena.

0:48.2

And so this was a range of questions, but generally in the field related to appetite regulation,

0:55.3

obesity, body fat, mass regulation, and so on.

0:59.7

And so there's a really interesting mix of questions that were put in.

1:03.8

And this is one of the things that is part of a Cigmatician premium subscription,

1:08.7

where our premium subscribers can submit questions that either

1:12.3

Alan and I answer during our Q&A episodes or one of us may do an individual Q&A episode,

1:19.0

as well as having experts like Dr. Giaenay from time to time on to do one as well. So this had a range

1:26.5

of interesting questions that go from a variety of topics.

1:30.7

We have questions on how liposuction may impact leptin levels because of you have this dramatic

1:37.4

reduction in at a post tissue. Could this impact leptin resistance? Looking at current research

1:42.9

around chronic energy restriction, and how that

1:46.0

affects appetite regulation in the long term. Looking at the concept of metabolic compensation,

1:52.4

and particularly through the lens of things like anorexia or obesity, looking at certain drugs like

1:59.9

serotonin dopamine re-uptake inhibitors and how they potentially

2:04.7

play a role in reducing appetite hunger. We look at things like the microbiome in the brain and

...

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