#529: Addressing Popular Claims About Cholesterol, Dietary Fat and Heart Disease
Sigma Nutrition Radio
Danny Lennon
4.8 • 626 Ratings
🗓️ 16 July 2024
⏱️ 134 minutes
🧾️ Download transcript
Summary
In episode 529 of Sigma Nutrition Radio, we discuss all things related to cholesterol, atherosclerosis, heart disease, and dietary fat. The discussion extensively covers the impact of LDL cholesterol and ApoB on atherosclerotic plaque progression, cardiovascular events, and the benefits of early LDL lowering interventions, particularly through the use of PCSK9 inhibitors alongside statins.
We address misconceptions prevalent in the low-carb and carnivore communities, dissect claims regarding saturated fats, and elucidate why atherosclerosis predominantly affects arteries and not veins. The episode sheds light on the nuanced mechanisms of cholesterol metabolism, the significance of different lipid particles, and the limited dietary impact on LP(a) levels.
Comprehensive evidence-based insights and practical recommendations for dietary patterns and cardiovascular health interventions are provided, offering clarity on these complex topics.
Note: This discussion is hosted by Simon Hill, and originally appeared as an episode of The Proof podcast.
Links:
- Subscribe to Sigma Nutrition Premium
- Receive our free weekly email: the Sigma Synopsis
- Episode with Professor Chris Packard
Timestamps:
- 07:19 Understanding Cholesterol and Lipoproteins
- 14:35 The Role of ApoB in Cardiovascular Risk
- 25:10 Atherogenic Lipoproteins and Their Impact
- 37:42 Causal Pathways and Biomarkers in Heart Disease
- 47:02 Understanding Residual Risk and Triglycerides
- 49:46 Paul Saladino’s Claims on LDL and Metabolic Health
- 01:03:01 Addressing Concerns About Lowering Cholesterol
- 01:16:16 The Importance of Early Intervention in Cholesterol Management
- 01:23:36 The Future of Cholesterol Management and Gene Editing
- 01:28:24 Atherosclerosis in Arteries vs. Veins
- 01:36:08 Dietary Interventions to Lower ApoB Levels
- 01:47:55 Modifying Keto Diet for Better Health Outcomes
- 01:56:33 Plant-Based Diets and Fat Consumption
- 02:05:10 Understanding Lp(a) and Its Impact on Health
Transcript
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| 0:00.0 | Hello and welcome to Sigma Nutrition Radio. My name is Danny Lennon. You're very welcome to another episode of the podcast. This is episode |
| 0:21.6 | 529. Today we're going to be talking about one of our favorite topics here on the podcast, and that is |
| 0:29.8 | all things to do with diet and heart disease, and specifically looking at some of the impacts on |
| 0:36.9 | markers like LDL cholesterol or apolypolyproprotein B, |
| 0:41.1 | or then going beyond that and looking at outcomes like atherosclerotic plaque progression |
| 0:46.4 | and then into actual cardiovascular events. |
| 0:49.9 | And within this, there's, as we have flagged many times, there are many claims online that seem to be |
| 0:57.0 | made that go against much of the consensus that we get from research on these topics, and can be |
| 1:02.9 | overwhelming and confusing. And obviously within that, there are also some really interesting |
| 1:07.5 | questions to ponder on and ideas that people have put forward. And so within |
| 1:12.5 | this episode, you're going to hear what I hope is hopefully a quite comprehensive rundown of |
| 1:17.5 | many of these different topics. And this actually stems from a conversation that Alan and I had |
| 1:23.9 | in person with Simon Hill, who back in the end of 2022, Alan and I, when we were in Sydney, |
| 1:31.4 | Australia, got to spend some time with Simon there, who is the host of the excellent podcast |
| 1:36.5 | The Proof, which many of you may be familiar with, and we were then in studio with him to record |
| 1:43.7 | this episode and this conversation that you |
| 1:46.0 | were now about to hear. |
| 1:47.9 | And we got through a bunch of things going through some of the basics from different types |
| 1:54.4 | of impacts of lipoproteins, their implication in atheroscleric plaque progression. |
| 1:59.9 | What do we know about damage to the artery? |
| 2:03.1 | What actually causes that? What is some of the causal pathways and things that are involved |
| 2:07.6 | within that? We then took a look at various different claims that you may hear from around the |
... |
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