#523 Hotcakes: Left Atrial Appendage Closure vs AC for Afib, Apixaban vs Rivaroxaban for VTE, Intensive LDL Targeting, GLP1s and Substance Use Disorders, and more
The Curbsiders Internal Medicine Podcast
The Curbsiders Internal Medicine Podcast
4.8 • 3.3K Ratings
🗓️ 27 April 2026
⏱️ 66 minutes
🧾️ Download transcript
Summary
Join us as we review recent practice-changing articles on left atrial appendage closure vs AC for AFib, apixaban vs rivaroxaban for VTE, intensive LDL targeting, GLP1s and substance use disorders, and more! Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Shani Herzig (@ShaniHerzig) Rahul Ganatra (@rbganatra), and Matt Watto (@doctorwatto).
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Credits
- Written and Hosted by: Rahul Ganatra MD, MPH; Shani Herzig, MD, MPH; Paul Williams, MD, FACP, Matthew Watto MD, FACP
- Cover Art: Rahul Ganatra MD, MPH
- Reviewer: Emi Okamoto, MD
- Technical Production: Pod Paste
- Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
Show Segments
- Intro, disclaimer
- Left atrial appendage closure vs anticoagulation in AF
- Apixaban vs rivaroxaban for VTE
- Intensive LDL targeting in ASCVD
- GLP1s and substance use disorders
- FDA approves Orforglipron
- E-cigarettes and cancer
- Early AM blood draws and sleep quality
- Outro
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Transcript
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| 0:00.0 | It's 2026 and we're about to have our three year anniversary of our Patreon at patreon.com |
| 0:06.0 | slash curbsiders. So to celebrate, we're offering the first 1,000 members who sign up free |
| 0:11.7 | house officer privileges for one month. That lets you get access to 70 plus bonus episodes |
| 0:17.7 | where Paul and I recap high yield pearls, pearls, answer listener questions, and give our |
| 0:22.4 | picks of the week. It's a lot of fun, so check us out at patreon.com slash curbsiders, or you can |
| 0:28.6 | click the link in the episode description to sign up. |
| 0:33.3 | Paul? |
| 0:35.0 | The guy who stole my diary has gone missing. |
| 0:43.1 | Yeah, I can't get there. |
| 0:44.7 | My thoughts are with his family, Paul. |
| 0:48.0 | That's a great one. |
| 0:50.2 | Thank you. |
| 0:51.0 | That was a... |
| 0:52.0 | Countryliving.com under the dark dad jokes section. I love it. The Curbsiders podcast is for entertainment, education, and information purposes only, and the topics discussed should not be used solely to diagnose, treat, cure, or prevent any diseases or conditions. For the more of the views and statements expressed on this podcast are solely the host and should not be interpreted to reflect official policy or position of any entity, aside from possibly cash like more honest, and affiliate outreach programs. |
| 1:14.7 | If indeed, there are any. In fact, there are none. Pretty much, we aren't responsible if you screw up. You should always do your own homework and let us know when we're work. Welcome back to the curbsiders. I'm Dr. Matthew Frank Guado, here with my great friend |
| 1:31.5 | in America's primary care physician, Dr. Paul Nelson Williams. Hey, Paul. Hey, Matt. How are you? |
| 1:37.7 | I'm doing well, Paul. Tonight is a hotcakes episode. We have a great guest, Dr. Shani Herzig, |
| 1:42.8 | and of course, Dr. Rahulganatra is with us as always. Paul, would you remind people, what is it that we do on curbsiders, and why are we here tonight? Sure, Matt. As a reminder, we are the internal medicine podcast. We use expert interviews to bring your clinical pearls and practice changing knowledge, except as you mentioned, this is one of our hotcakes episode. So this time, the experts are not really us, me and you, Matt, but we actually do have some bona fide experts with us, including the great Dr. U. Holganacha or resident epidemiologist. We go through some articles that we thought were especially interesting or perhaps relevant to practice or just things that we wanted to talk about. And then we get to listen to smart people talk about how they think about those articles, which is always super educational. So as I mentioned, we are joined by Dr. Rahul, Kanacha. Rahul, how are you? I'm doing great. Paul, how are you? I'm good. Thank you for asking. Paul, I want to mention to the audience that I was in Boston this month and I got to see Rahul in person. Actually, I brought my whole |
| 2:37.4 | family to his house, which I apologize to you, Rahul, for my kids running all over the place. |
| 2:42.7 | It was perfect. He got to meet my family. I got to meet his wife. It was great. We got to talk |
| 2:47.8 | for a while. Rahul, my kids are like, Rahul is so nice. I'm like, yeah, why wouldn't he be? No, I had just cut up a honey-dew melon, and so I had like a bowl of fruit to offer. I think that really went over well. This is maybe the most wholesome thing I've ever heard. Yeah, no, I'd love to hang out with Rojole, but yeah, I also am not going to Boston anytime soon. |
| 3:15.6 | Well, Paul, that's your loss. But if you're ever in town, I would, I would just barge into his house with your family and just say hi. |
... |
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