#508: ASCVD Risk & Lipids Update! PREVENT, ApoB, Lp(a) + Next-Gen Therapies

The Curbsiders Internal Medicine Podcast

Higher Education, Health & Fitness, Medicine, Science, Education

4.8 • 3.1K Ratings

🗓️ 15 December 2025

⏱️ 95 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Master cardiovascular disease prevention! Learn how to apply the new PREVENT risk calculator, use the CPR framework for risk reclassification, and interpret ApoB and Lp(a) in modern lipid management. We’re joined by Dr. Laurence Sperling to break down what’s new in ASCVD risk assessment and prevention.

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Show Segments

Intro
Case 1 from Kashlak
Risk assessment framework
ApoB and Non-HDL cholesterol
Lipoprotein(a) and its importance
The PREVENT risk score and its implications
Statins and other lipid lowering therapies
The role of diet and lifestyle in lipid management
Case 2 from Kashlak
Familial Hypercholesterolemia diagnosis and management
Key takeaways
Outro

Credits

Producer, Writer, Shownotes, Infographic, and Cover art: Ben Furman, MPH
Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP
Reviewer: Leah Witt, MD
Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
Technical Production: PodPaste
Guest: Laurence Sperling, MD

Disclosures

Dr. Sperling reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.

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Transcript

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0:00.0	Paul, why did the girl quit her job at the donut factory?
0:06.0	I don't know, Matt.
0:07.0	Why did the girl quit her job at the donut factory?
0:10.6	Because she was fed up with the whole business.
0:15.0	All right.
0:16.6	The whole business, Paul.
0:17.9	No, I got it.
0:37.7	I love donuts. The curbsiders podcast is for entertainment, education, and information purposes only, and the topics discussed should not be used solely to diagnose, treat, cure, or prevent any diseases or conditions. For the more of the views and statements expressed on this podcast are solely those of the host and should not be interpreted to reflect official policy or position of any entity, aside from possibly cash like more a hospital and affiliate outreach programs.
0:38.7	If indeed, there are any.
0:39.4	In fact, there are none.
0:40.8	Pretty much, we are responsible if you screw up.
0:42.2	You should always do your own homework and let us know when we're wrong.
0:50.7	Welcome back to the curbsiders.
0:54.7	I'm Dr. Matthew Frank Guaddle here with my great friend in America's primary care physician, Dr. Paul Nelson Williams. Hey, Paul. Hey, Matt. How are you? I'm doing well. This is an episode
1:02.1	on cardiovascular risk reduction and lipids with a true expert, Dr. Lawrence Spurling and Paul,
1:09.5	before we get to our guest bio, could you tell us what is it that
1:12.3	we do on curbsiders? Because I am, I'm tired and I'm struggling a little bit right now. You're doing
1:16.8	all right, Matt? Yeah, just as a reminder to you and our audience, we are the internal medicine
1:21.8	podcast, believe it or not. We use expert interviews to bring you clinical perils and practice
1:25.4	changing knowledge. Matt, as you mentioned, tonight we talked to Dr. Lawrence Spurling about lipids and evaluation, so I'll get to that
1:33.0	in the second. So let me tell you about Dr. Spurling first, Matt. He is the founder and was the
1:38.4	director of the Heart Disease Prevention Center at Emory. He is currently the Katz Professor in
	...

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