The Joe Roggan Experience

Train by day Joe Rogan Podcast all day.

Hello Rhonda.

Hello Joe. You're the only person that's ever come in sat down and said, oh this is good I'm getting a

cortisol rush. She said you're getting a cortisol rush from the feeling of about to do a part.

Yeah, actually I could have gone a little more detail, but I was like,

hmm.

Yeah, you know, so that feeling of anxiety, you know, that like you get, before you get on stage I mean you're a

comedian I'm sure you're really familiar with that you actually are expressing a

chemical called de noorfin and this this is an endogenous chemical in your brain and it binds to something called the

Kappa opioid receptor. It's kind of like the counter of the endorphine which

binds to the new opioid receptor. So the endorphins are the feel good. Well its nemesis is the

dinorphin which is that anxiety-like feeling. So but here's the interesting part. That anxiety-like

feeling that you feel

before you're you know going to do something like you're you know really that you care

about or that's kind of anxiety provoking for me public speaking does it I

get it right before I'm going to do it you know

give a talk or something or do a podcast in front of you know 500,000 people

so that dinorphine binding to the Kappa opioid receptor, what it does is it upregulates the

mew opioid receptor so that after you get that anxiety feeling, you have a better endorphine

rush because you upregulate the mewopioid receptors which bind to the endorphins

the feel-good ones and you actually become sensitized to them.

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