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Plenary Session

5.03 - VPs Grand Rounds Lecture - Evidence Based Medicine - Will it Survive?

Plenary Session

Vinay Prasad, MD MPH

Health, Medicine, Policy, Oncology, Science & Medicine

4.7789 Ratings

🗓️ 13 July 2022

⏱️ 51 minutes

🧾️ Download transcript

Summary

How to think about when and how to do RCTs? What are the limitations to observational studies? Smoking. Parachutes. Dostarlimab. Guarantee Time Bias. Confounding. Multiple Hypothesis testing and more

Transcript

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0:00.0

I hope so too. Thank you so much for that kind introduction. And I wanted to put together a talk that I thought people in general internal medicine and hopefully the subspecialties will find of interest.

0:11.7

And so I think, I hope this delivers. And feel free to toss any questions you have in the Q&A and I will answer them as best I can. I'll try to leave some time open for questions.

0:23.1

I want to start with this, evidence-based medicine.

0:25.6

You know, will it survive?

0:26.7

The title was just provocatively title so that I could entice you to come.

0:31.0

But recently I've heard very interesting things, which are that, you know, randomized trials,

0:36.9

they're overrated.

0:37.8

You can't have a randomized trial for every question in life.

0:39.9

In fact, probably most of the things you did today, you don't have a randomized trial for,

0:43.3

you woke up, you brushed your teeth, you got dressed.

0:45.4

There are no randomized trials that support that.

0:47.6

Not to mention, there are no, we didn't require a randomized trial to know that smoking was harmful.

0:53.6

And we certainly don't require a randomized trial to know that smoking was harmful. And we certainly don't require

0:54.6

a randomized trial to know that wearing a parachute when you fall out of an airplane is beneficial.

0:59.0

So smoking, parachutes, all those day-to-day tasks, they don't require randomized trials.

1:03.6

They're overrated. We don't need them for every question. And that's what I think increasingly

1:07.6

people argue. So, you know, this is going to be drawing upon a paper that I wrote with Logan Powell, who's based out of Texas.

1:13.6

You know, are those good counter examples?

1:16.6

So let me walk you through this axis.

1:18.6

This is how I think about healthcare.

1:19.6

You know, healthcare is a unique type of intervention.

1:22.6

It's an intervention that we're doing to make people feel better, be better off in some way. And you can imagine a spectrum of

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