49ers take next-man-up mentality into Week 4 vs. Jaguars

49ers Talk: A San Francisco 49ers Podcast

NBC Sports Bay Area

Nfl, Football, Matt Maiocco, San Francisco 49ers, Sports

4.6 • 988 Ratings

🗓️ 25 September 2025

⏱️ 38 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Despite their undefeated status, the Nick Bosa-less 49ers must persevere as the Jacksonville Jaguars visit Levi's Stadium this Sunday. Matt Maiocco and Jennifer Lee Chan discuss who will step up in Bosa's place and how San Francisco can adapt in other injury-bitten position groups. Plus, Matt and Jennifer detail how Demarcus Robinson will integrate back into the fold and how it affects the receiving corps. Finally, the nominees for the Pro Football Hall of Fame's Class of 2026 have been announced, and Matt and Jennifer choose the most outstanding former 49er candidates.

Transcript

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0:00.0	Savings. Big O savings. Get up to $120 in savings and select Michelin Tires with installation
0:08.1	purchase. Plus zero interest if paid in full within 12 or six months. Big O Tires, the team you trust.
0:20.1	Reality has set in for the 49ers as a return to the practice field to get set for their week four game.
0:26.6	The 49ers are 3 and 0, but all is not perfect for this team.
0:30.6	One of their most valuable players, Nick Posa, is out for the season, and there are real questions about how or if they can compensate for what
0:39.1	the 49ers are lacking without Bosa on the field. Meanwhile, the week opens with at least a little
0:44.6	question, too, about who will line up a quarterback. Brock Purdy appears to be tracking toward a
0:49.5	return to action, while Mack Jones is now dealing with an injury of his own.
0:58.1	Jennifer Lee Chan and I will bring you up to date on the 49ers as they prepare for this week's game against the Jacksonville Jaguars.
1:00.5	We'll also tell you which former 49ers made the list for nominations for the
1:04.5	Pro Football Hall of Fame class of 2026.
1:07.7	We'll have all that and much more on this episode of 49ers talk coming at you right now.
1:13.2	Welcome to another episode of 49ers talk on NBC Sports Bay Area.com.
1:19.1	Introducing your hosts, Matt Mayoko and Jennifer Lee Chan.
1:23.6	All right, this is 49ers talk, brought you by Big O Tires.
1:27.0	Drive away knowing you got the best deal on the road with Big O Tires low price guarantee.
1:32.2	Check out this week's specials and set an appointment at bigotires.com.
1:36.7	Bigot tires, the team you trust.
1:40.5	I'm Matt. She's Jennifer.
1:41.9	We're back to work as the 49ers are 3 and 0.
1:46.0	They got to be feeling good about 3 and 0, right?
1:48.3	I would think so. I mean, you think about how many players have been missing from the lineup through these past three games.
	...

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