#490: How Does Exercise Impact Beta-cell Function in Type 2 Diabetes? – Mark Lyngbæk, MD

Sigma Nutrition Radio

Danny Lennon

Nutrition, Health & Fitness

4.8 • 633 Ratings

🗓️ 1 August 2023

⏱️ 58 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Links:

About This Episode:

The management of type 2 diabetes has long been a challenge, but a new study conducted by researcher Mark Lyngbaek and his colleagues has the potential to add important considerations to the approach to treatment. Titled the "DOSE-EX" randomized clinical trial, their study uncovers the impact of exercise and weight loss on beta-cell function, a key factor in diabetes progression.

DOSE-EX is a four-armed randomized trial involving 82 individuals with newly diagnosed type 2 diabetes. The participants were divided into four groups: standard care, calorie restriction, calorie restriction with exercise three times per week, and calorie restriction with exercise six times per week. Over a span of 16 weeks, the researchers assessed the effects of these interventions on beta-cell function using various indicators.

The study's findings are incredibly interesting, demonstrating that exercise in combination with diet-induced weight loss leads to a substantial improvement in glucose-stimulated beta-cell function. Importantly, the results indicate the importance of considering both: a) the exercise dose, and b) the methodology of assessing beta-cell function, when evaluating intervention effectiveness.

In this episode, Dr. Lyngbaek will elucidate the implications of these findings for the management of type 2 diabetes. We will explore the potential of exercise as a therapeutic tool, its optimal dosage, and the considerations for integrating it into individualized treatment plans.

About The Guest:

Dr. Mark Lyngbæk is a physician, currently in an introduction position at the Department of Rheumatology and Internal Medicine 2 at Holbæk Hospital, and also a PhD student at the Centre for Physical Activity Research at Rigshospitalet.

His research has looked at exercise, beta-cell function and type 2 diabetes. He is supported by a research grant from the Danish Diabetes Academy, which is funded by the Novo Nordisk Foundation (grant number NNF17SA0031406). The Centre for Physical Activity Research is supported by TrygFonden (grants ID 101390, ID 20045, and ID 125132).

Subscribe to PREMIUM

Transcript

Click on a timestamp to play from that location

0:00.0	Hello and welcome to Sigma Nutrition Radio, the podcast that brings you evidence-based discussions all about the science of nutrition and health.
0:22.2	We are at episode 490 of the podcast. My name is Danny Lennon. You are very welcome.
0:29.0	Today we are going to be talking all about beta cell function, type 2 diabetes and the potential role for exercise interventions.
0:38.8	Today I'm going to be talking with Mark Lingbeck, who is a physician currently in a position at the Department of Rheumatology
0:44.5	and internal medicine at Holbeck Hospital in Denmark. And he's also a PhD student at the
0:50.6	Center for Physical Activity Research. And there he has work that has a research
0:56.3	grant from the Danish Diabetes Academy, where he's been looking in at interventions that could
1:01.1	potentially help in type 2 diabetes. And one of their particular papers that he and his colleagues
1:08.0	have published recently that I already enjoyed reading was looking
1:11.5	at exercise interventions and their potential benefit for type 2 diabetes patients, specifically
1:18.4	looking at how they impact beta cell function.
1:21.1	And we're going to focus in on that particular study in this episode today and go through
1:26.3	it in some detail as well as how this
1:28.2	plays a role into understanding concepts like beta cell function and how that can play a role
1:34.0	in type 2 diabetes pathogenesis and also potential for type 2 diabetes remission if we can
1:40.3	achieve restoration of beta cell function. So we're going to dive into all of that today.
1:45.4	Now, for those of you who are Sigma Nutrition Premium subscribers,
1:48.7	you will be able to get detailed study notes to this episode
1:51.2	by just clicking the link in the description box right now in your feed.
1:55.4	You'll also be able to get a full transcript to this episode,
1:58.8	as well as our previous ones.
2:00.7	If you're listening on our public feed
	...

Please login to see the full transcript.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from Danny Lennon, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Danny Lennon and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.