489: Histamine Intolerances, Mast Cells, Our Nervous System, and Liver with Dr. Jess Peatross
Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40
Natalie Jill
4.8 • 635 Ratings
🗓️ 31 October 2025
⏱️ 56 minutes
🧾️ Download transcript
Summary
Could your racing thoughts and underlying anxiety be causing your mysterious hives, heart palpitations, and unexplained allergic reactions?
After my own shocking hive outbreak following surgery and Bali belly, I dove deep into the world of histamine and mast cells. Dr. Jessica Peatross, the MD who's become known as the "surgeon of figuring out what's really going on," reveals why your nervous system might be the hidden trigger behind your mystery symptoms. She explains why midlife women suddenly develop histamine issues out of nowhere, the shocking connection between anxiety and mast cell activation, and why your body might be pushing toxins out through your skin when it can't eliminate them normally. We dive into game-changing protocols including specific binders that act like sponges for excess histamine, why addressing your gut is non-negotiable, and how a simple dissolving strip might calm your overactive mast cells. Dr. Jess shares her "magic trick" binder protocol, explains which supplements actually work for mast cell stabilization, and reveals why treating the nervous system FIRST is crucial for any healing protocol to work. Whether you're dealing with unexplained hives, chronic inflammation, or mystery symptoms that appeared out of nowhere, this conversation will change everything you thought you knew about histamine and healing.
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Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen.
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Transcript
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| 0:00.0 | histamine reactions, mast cells. What does that all mean? And where the heck does it come from? |
| 0:06.1 | And why does it seem like histamine problems can come out of nowhere in midlife especially? |
| 0:12.5 | And what does this have to do with toxic load, how we're aging, how we're healing? And what can |
| 0:18.3 | we do about it? Is it a food allergy? Is it something we can overcome? |
| 0:22.2 | What do we need to know? Welcome to Midlife Conversations. I'm your host, Natalie Gill, |
| 0:27.7 | and I'm passionate about having amazing conversations that matter to us midlife women. |
| 0:32.9 | On this podcast, I do what I do best, taking complicated health topics and breaking them down simply |
| 0:38.2 | so that we can optimize aging together. I share actionable steps to help you thrive in what I |
| 0:44.1 | believe are our best years to come. Join me as I interview the most inspiring people living |
| 0:49.5 | their best midlife years and dive into essential topics like hormone changes, health optimization, |
| 0:54.5 | weight management, blood sugar, emotional well-being, relationships, beauty, and so much more. |
| 1:01.2 | Today I have one of my favorite people on as a guest, Dr. Jess MD. We love talking to Jess. |
| 1:08.0 | Now, I personally am friends with her. |
| 1:11.1 | So unfortunately, I have her phone number. |
| 1:13.5 | That's what she might say. |
| 1:14.7 | Because when something's going on, I happen to have a lot of friends that are doctors. |
| 1:19.0 | And she is one that is this, I don't even know how to call you. |
| 1:22.6 | You're like a surgeon to what's going on. |
| 1:24.9 | Like you're really good at getting in there and figuring out what is the thing that no one else is seeing in you and what do we how to do about it. So that's what I'm going to call you. You're like a surgeon of figuring out what's going on, Jess. That's how I'm going to call what I'm going to call you. Has anyone ever called you that? No, but you're pretty creative. I like i like that actually no one has ever said anything like |
| 1:44.3 | that to me before so so jess is an actual md um but she is a true functional md like she there is |
| 1:52.4 | there's like the far one side of the spectrum the far another side and she really uses that a whole |
| 1:58.3 | gamut she is not set in it's only this way or it's only that way. |
... |
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