479: The Neuroscience of Chronic Pain: Why Your Brain Gets Better at Creating Pain (And How to Teach It to Stop) with Ashleigh Di Lello
Midlife Conversations with Natalie Jill: Fat Loss, Hormones & Health for Women Over 40
Natalie Jill
4.8 • 635 Ratings
🗓️ 16 September 2025
⏱️ 69 minutes
🧾️ Download transcript
Summary
What if the chronic pain that's been ruling your life isn't actually about physical damage—but about your brain trying to protect you from threats it perceives based on your entire life history?
Ashleigh Di Lello should be dead. At 13, doctors told her she wouldn't survive her teenage years after a mysterious viral infection began shutting down her organs. Twenty years later, after building a successful Broadway career, a failed hip surgery left her unable to walk and in excruciating pain that no treatment could touch…not even powerful opioids. After trying over 200 treatments and being told by specialists it was "downhill from here," Ashleigh made a decision that would revolutionize how we understand chronic pain.
In this episode, we dive deep into a topic that's been both personal and transformative for me: the connection between pain and the brain. For years, I believed that pain was only the result of real, physical injuries. But after my own journey through back surgery and chronic pain, I started to question: what if our brains play a bigger role in how we experience pain than we realize?
Discover why Type A personalities are more prone to chronic pain, how your brain actually gets BETTER at creating pain the more you experience it, and why doing everything "right" for your body might not be enough if your nervous system is stuck in survival mode. Ashleigh reveals the critical difference between regulating your nervous system (managing symptoms) versus rewiring it (changing how your brain processes pain entirely), and shares the exact paradigm shift that allowed her to walk again after five years of disability.
Whether you're dealing with chronic pain, unexplained symptoms, or simply curious about the incredible power of the brain-body connection, this episode will fundamentally change how you think about healing.
Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube
Learn More About Ashleigh Di Lello:
Instagram ➜ https://www.instagram.com/ashleighdilello
Website ➜ https://www.ashleydilello.com
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Transcript
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| 0:00.0 | And I really believe that deep down inside my spirit knew that I wasn't just sent here to die |
| 0:05.5 | at 13 years old. And I really believe that's what I was accessing when they were telling me I |
| 0:10.4 | needed to accept I was dying. There was a part of me that just didn't connect with that as being |
| 0:15.0 | true. Before we get started on today's midlife conversation, I want to share one of my favorite |
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| 0:32.0 | you right now, if you're like me, you've probably noticed that your body might have become more |
| 0:35.7 | sensitive as we've aged. Stress hits harder, sleep feels lighter, and all that time on devices like our cell phones, |
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| 1:20.4 | vitality. |
| 1:21.3 | And really important here, it helps to harmonize the effects of EMFs. |
| 1:25.5 | And I know you've heard about EMFs and what they can do to our |
| 1:28.3 | bodies. So those invisible stressors were exposed to every day from phones, Wi-Fi, |
... |
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