#477: Effect of Different Diets on Cholesterol, Lipoproteins and Discordance – Ian Davies, PhD
Sigma Nutrition Radio
Danny Lennon
4.8 • 633 Ratings
🗓️ 4 April 2023
⏱️ 54 minutes
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Summary
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Introduction:
Discordance between low-density lipoprotein particle (LDL-p) and low-density lipoprotein cholesterol (LDL-C) occurs when the levels of these two biomarkers do not match up as expected. Discordance between Apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) is similar, except rather than counting just LDL particles, ApoB is a measure of the numbers of lipoproteins that have an ApoB attached.
Discordance between ApoB and LDL-C can lead to either an underestimate or overestimate of ASCVD risk. And therefore there may be important implications for someone who does have discordance. Additionally, it is such cases that suggest that a measurement of ApoB may provide additional information beyond traditional lipid measures in assessing a person's cardiovascular risk.
Recent work from researchers at Liverpool John Moores University has investigated whether discordance is associated with certain dietary patterns.
In this episode, one of the researchers involved, Dr. Ian Davies, is on the podcast to discuss this work in addition to wider questions in the diet-lipids-CVD field that remain to be answered.
Transcript
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| 0:00.0 | Hello and welcome to Sigma Nutrition Radio. |
| 0:17.1 | This is the podcast where you get to hear discussions all about nutrition science, health, |
| 0:21.4 | and related topics. My name is Danny Lennon and we are at episode 477 of the podcast. And today I'm |
| 0:30.8 | going to be talking to Dr. Ian Davis, who is a reader, a nutritional scientist based at Liverpool |
| 0:37.2 | John Moore's University, and his |
| 0:39.7 | primary research interest has been related to cardiovascular disease, and particularly, as we'll |
| 0:45.3 | talk about today, looking at things at lipoproteins and other blood lipids, and their potential |
| 0:50.5 | implications there, and then he has a much broader interest and publication record on a variety of topics |
| 0:56.9 | that relate to Daya another lifestyle choices |
| 0:59.7 | and how they impact cardiometabolic disease risk. |
| 1:03.1 | But of course, we're gonna be focusing in today, |
| 1:05.4 | primarily in on cardiovascular disease |
| 1:08.1 | and specifically atherosclerosis development with a view of looking at |
| 1:12.6 | the impact of different lipoproteins, looking at markers like LDL cholesterol, APOB, the concordance |
| 1:21.1 | or discordance between those things, the implication for that, and then what research we potentially have on different dietary patterns |
| 1:29.4 | of not only how they affect those markers, but do certain changes seem to correlate with |
| 1:35.0 | a degree of discordance. And Dr. Davis has published work that's also looked at various types |
| 1:41.7 | of dietary patterns, including carbohydrate-restricted diets, and trying |
| 1:46.5 | to investigate in some way do some of the hypotheses that are put forward in that area, |
| 1:52.5 | stack up. |
| 1:53.0 | So as we've discussed on this podcast before, there's been many ideas around how for carbohydrate-restricted |
| 2:00.0 | diets, even though in some cases there may be |
... |
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