#470: Melatonin, Meal Timing & Glucose Tolerance

Sigma Nutrition Radio

Danny Lennon

Nutrition, Health & Fitness

4.8 • 633 Ratings

🗓️ 7 February 2023

⏱️ 71 minutes

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Summary

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Description:
Meal timing has been a popular, and at times controversial, topic of interest in nutrition. Despite much speculation over the years as to potential advantages to specific meal timing or meal frequencies, for many outcomes there seems to be little pragmatically meaningful difference. For example, when accounting for calorie and macronutrient intake, there is little to no effect of meal timing on body composition, blood pressure, and energy expenditure.

However, just because there is little evidence for the importance of meal timing in relation to those outcomes, this should not be interpreted to mean there is no impact of meal timing on all health outcomes.

One area where meal timing may be an important factor is in relation to glucose tolerance and glycaemic control. For example, it has been consistently shown that eating at 'biological night' leads to worse postprandial glucose responses. And this could be particularly important for those with insulin resistance, pre-diabetes or type 2 diabetes.

Some of the most influential work in this area has been done by Marta Garaulet's lab at the University of Murcia. One of the central aspects they have published on has been the interaction between food timing and melatonin levels, and how this in turn affects glucose tolerance and cardiometabolic markers.

In this episode, Danny and Alan discuss the topic of meal timing and glucose tolerance, using a recent study from Garaulet et al. to highlight some important concepts.

Transcript

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0:00.0	Hello and welcome to Sigma Nutrition Radio. This is episode 470 of the podcast. I'm your host, Danny Lennon. You are very welcome to or back to
0:24.7	the podcast. And indeed, if you listen to last week's episode all about chrononutrition,
0:30.8	then this episode will be a perfect addition to that. But of course, if you have yet to listen
0:37.1	to episode 469, do not worry, you should you have yet to listen to episode four six nine
0:38.5	do not worry you should still be able to get to grips with this episode
0:42.6	listening alone although they do complement each other so if you do find this
0:47.1	topic of meal timing circadian rhythms cardiometabolic effects interesting then I
0:53.7	think it's worth going back at some point and listening
0:56.0	to the previous episode of this podcast. Now, this particular episode is a discussion that
1:02.8	Alan and I had for our live event that took place in Berlin, Germany. So a special thank you
1:09.8	to everyone who attended that event.
1:12.4	And over the course of the day,
1:13.8	we had a number of different sessions,
1:15.7	but one of them was a discussion about a specific research paper
1:20.2	that looked at the topic of meal timing and glucose tolerance
1:24.1	and tied in some of the circadian aspects
1:26.4	that we talked about last week. And so that is what I'm
1:29.1	going to play for you here today. And so that paper I will link to in the show notes to this episode,
1:35.9	if you want to go and check it out. The title of it is Interplay of Dinner Timing and MTNR1B
1:42.7	type 2 diabetes risk variant on glucose tolerance and insulin secretion,
1:47.8	a randomized crossover trial. And this was published by Marta Garolait and Jesus Lopez-Mingwith
1:54.6	from the University of Murthia in Spain. They were the lead authors on this particular paper.
	...

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