4.6 • 29.1K Ratings
🗓️ 3 October 2025
⏱️ 25 minutes
🧾️ Download transcript
Sam Harris speaks with Michael Osterholm about his new book, The Big One: How We Must Prepare for Future Deadly Pandemics. They discuss the lessons learned from the COVID-19 pandemic, the major mistakes made in the public health response—including lockdowns, school closures, and border policies—the science of airborne versus droplet transmission, the promise and controversy of mRNA vaccines, the reality of vaccine adverse events, the politicization of vaccine hesitancy, and the erosion of scientific institutions like the CDC and HHS under the Trump administration. Looking forward, they explore the characteristics of a future, more deadly pandemic—what Osterholm calls "The Big One"—and what we should be doing to prepare for it.
If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.
Click on a timestamp to play from that location
| 0:00.0 | Welcome to the Making Sense podcast. This is Sam Harris. Just a note to say that if you're hearing this, you're not currently on our subscriber feed, and we'll only be hearing the first part of this conversation. In order to access full episodes of the Making Sense podcast, you'll need to |
| 0:21.5 | subscribe at samharris.org. We don't run ads on the podcast, and therefore it's made |
| 0:26.5 | possible entirely through the support of our subscribers. So if you enjoy what we're doing here, |
| 0:31.2 | please consider becoming one. I am here with Michael Osterholm. |
| 0:38.2 | Michael, thanks for joining me. |
| 0:39.8 | Thank you for having me. |
| 0:41.2 | So you have written an alarming book titled The Big One, How We Must Prepare for Future Deadly Pandemics. |
| 0:48.8 | You co-wrote that with Mark Olshaker. |
| 0:52.1 | And we're going to get into that. |
| 0:53.9 | I mean, obviously we're, I think, as a presage to your book, I mean, actually your book |
| 1:00.6 | accomplishes much of this as well. |
| 1:02.3 | I think we should do a bit of a post-mortem on the COVID pandemic and what we've learned |
| 1:07.1 | or failed to learn from that experience. |
| 1:09.6 | That was as bad as that was, that was a kind |
| 1:11.5 | of dress rehearsal for the thing you're imagining, which would be quite a bit worse. Before we jump in, |
| 1:16.2 | what is your scientific background and what are your responsibilities as an epidemiologist at this |
| 1:22.1 | point? Well, I actually was fortunate enough to know when I was in seventh grade, I wanted to become |
| 1:27.1 | a medical detective. |
| 1:28.4 | It turned out that someone in my small Iowa farm town actually subscribed to the New Yorker. |
| 1:33.5 | And at that time, there were a series of articles in there by Burton Rogey, which were medical whodunnits, |
| 1:39.6 | basically kind of the CDC versions of these outbreaks. And when I read that, I said, this is what I want to do. |
| 1:46.1 | So when I graduated from undergraduate, I immediately went to graduate school at the University of |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Waking Up with Sam Harris, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Waking Up with Sam Harris and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2025.