424: We may need to reconsider the power of antidepressants | Internal medicine doctor Austin Perlmutter, M.D.

The mindbodygreen Podcast

mindbodygreen

Alternative Health, Health & Fitness

4.5 • 2.1K Ratings

🗓️ 4 August 2022

⏱️ 39 minutes

🔗️ Recording | iTunes | RSS

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Summary

Austin Perlmutter, M.D.: “Is inflammation involved in our poor mental health epidemic today? I believe the answer is yes.” Austin, an integrative medicine doctor and New York Times bestselling author, joins mbg co-CEO, Jason Wachob, to discuss the complicated link between depression and serotonin, plus: - How to treat depression beyond medication (~13:01) - How to prevent depression before it becomes a problem (~14:32) - How social media and the news can contribute to inflammation (~16:57) - How to identify inflammatory relationships (~28:27) - Top foods for brain health (~30:05) Referenced in the episode: - Austin's book, Brain Wash. - Visit Big Bold Health. - Study in Molecular Psychiatry on the role of serotonin in depression. - mbg article discussing this study. - Austin's Instagram video discussing the serotonin study. - A study on the Mediterranean diet and depression. - Shop Himalayan tartary buckwheat. Jason's homemade Perfect bar recipe: - 1 ½ cup Santa Cruz Organic Light, Crunchy Peanut Butter - ¼ cup Big Bold Health Himalayan tartary buckwheat - ¼ cup Sunfood Superfoods Raw Organic Milled Flaxseed - 2 tbsp Lakanto Monkfruit - 1 tbsp Wholesome Raw & Unfiltered Organic White Honey - 1 handful (or whatever feels good) of Hu Chocolate Gems. - Mix nut butter, flours, honey, and monkfruit in bowl. - Lay out batter in a glass pan over parchment paper, and even out with a roller. - Drop in as many gems as you like. - Put in freezer for 90 minutes, then put in the fridge and slice up into squares. We hope you enjoy this episode sponsored by Sonos, and feel free to watch the full video on Youtube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	Welcome to the MyBuddyGreen podcast. I'm Jason Wackib, founder and co-CEO of MyBuddyGreen and
0:05.6	your host. Dr. Austin Pearlmutter is an internal medicine doctor who now focuses on helping people
0:13.0	improve their health through better decisions, neuroscience, and lifestyle interventions.
0:18.8	He is a New York Times bestselling author of Brainwash and Senior Director of Science and Clinical
0:25.7	Innovation at Big Old Health. Austin, welcome. Jason, great to see you again. Thanks for having me.
0:33.8	Great to see you. You know, we're here today to talk about a pretty interesting
0:41.4	paper to say the least, which came out about a week ago in Nature's Molecular Psychiatry.
0:49.5	And this paper is getting a ton of attention because essentially what it does is cast
0:54.3	serious doubt about the role that serotonin, specifically serotonin deficiency, plays in depression,
1:04.2	which essentially calls into question the prescription of SSRIs for those suffering from depression,
1:13.9	kind of a bombshell. So I saw this paper quickly. I saw what you were putting on Instagram and
1:21.1	I thought what you were putting out was was really interesting and smart and thought provoking.
1:27.6	So I'm going to pause there. What do you think about the implications of this research?
1:34.2	Well, Jason, I think we need to start with a couple of facts. One is depression is a huge deal
1:40.2	in the United States and around the world. We're talking hundreds of millions of people right now
1:45.0	who are suffering from clinical depression. And there are probably a lot of other hundreds of
1:50.0	millions, if not more, people suffering from subclinical depression, meaning they don't quite
1:54.4	meet the criteria for that diagnosis. And when we think about how that's going, we realize that
2:02.1	even with the best therapies, which right now would be something like a SSRI or selective serotonin
2:08.0	reuptake inhibitor, there's probably a third to even more people who are not really getting
2:13.9	remission, not really getting a significant benefit. So that's kind of the state of things. And it's
2:19.5	even worse in countries that don't have great access to care where probably 85% plus of people
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