418 - Update: COVID-19 Vaccines and Immunocompromised Patients
Public Health On Call
The Johns Hopkins Bloomberg School of Public Health
4.6 • 644 Ratings
🗓️ 14 January 2022
⏱️ 19 minutes
🧾️ Download transcript
Summary
What do we know now about the number of doses needed for people on immunosuppressant medications to be protected from severe COVID? What about the use of "passive" protection like monoclonal antibodies? Why are negative antibody tests more helpful than positive ones? Why are large agencies like the CDC and FDA not discussing individualized medicine when it comes to vaccine protocols? What's the next step in researching COVID-19 vaccine protocols for this unique population of patients? Johns Hopkins transplant surgeon Dr. Dorry Segev returns to the podcast to talk with Stephanie Desmon about what we now know and what still needs to be figured out.
Transcript
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| 0:00.0 | Welcome to Season 5 of Public Health On Call, a podcast from the Johns Hopkins Bloomberg School of Public Health. |
| 0:13.0 | I'm Joshua Sharfstein, Vice Dean for Public Health Practice and Community Engagement, and a former |
| 0:19.1 | health commissioner here in Baltimore, Maryland. |
| 0:21.7 | Our goal with this podcast is to bring scientific evidence and experience to shed light on critical |
| 0:27.5 | health issues. If you have questions or ideas for us, please send an email to public health |
| 0:33.0 | question at jhhhu.edu. That's public health question at jh.u.edu for future podcast episodes. |
| 0:41.7 | Hi, I'm Lindsay Smith Rogers, producer of Public Health On Call. Today, Stephanie Desmond talks again to Dr. |
| 0:48.1 | Doris Sigev, a prolific Johns Hopkins researcher and transplant surgeon, about what we've learned |
| 0:53.7 | in terms of immunocompromised |
| 0:55.3 | people during the pandemic and whether the vaccines actually protect them from COVID-19 or |
| 1:00.7 | if there's more we need to do. Let's listen. |
| 1:03.0 | Dori Segev, thanks so much for joining me. |
| 1:06.0 | Yeah, great to talk to you again. |
| 1:08.0 | Today I'd like to talk about immunocompromised patients and vaccination. |
| 1:13.6 | I know that you have been studying them throughout the pandemic. |
| 1:18.4 | And what you found is that for many immunocompromised patients, the regular two-dose regimen |
| 1:24.0 | didn't work. |
| 1:25.0 | And in many cases, the three-dose regimen didn't work. So I'm |
| 1:28.1 | if you can sort of tell me where we are right now. Yeah. So there are somewhere on the order of |
| 1:34.1 | about five to seven million immunocompromised people living in the United States who are all kind |
| 1:40.0 | of struggling and have been struggling for a year with how do we achieve vaccine-induced immunity? |
| 1:47.7 | How do we know if we have it? How many shots do we need? Which platform do we need? When is it |
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