#385: Insulin Resistance & Diet

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 4 May 2021

⏱️ 77 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode we explore the causes of insulin resistance, and the dietary modifications that may help those with insulin resistance.

We discuss how insulin resistance is a complex metabolic disorder, that goes beyond one single pathway or cause. There is also a discussion on the mechanisms of insulin resistance pathogenesis. Specifically, we talk about the accumulation of ectopic fat. Ectopic fat is the storage of triglycerides in tissues other than fat tissue, such as the liver, skeletal muscle, heart, and pancreas.

There is also an overview of the Twin-Cycle Hypothesis, which was discussed in more detail in a previous episode with Prof. Roy Taylor. In addition, we give special mention to liver fat accumulation and the relationship between insulin resistance and non-alcoholic fatty liver disease (NAFLD).

Then various diet interventions are assessed for their potential usefulness to those with insulin resistnace. This includes different diet types (e.g. whole-food plant-based diet, low-carbohydrate ketogenic diet, etc.), role of macronutrients, pre-loading studies, and the role of meal timing and circadian effects.

Find the show notes at https://sigmanutrition.com/episode385

Transcript

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0:00.0	Hello and welcome to another episode of Sigma Nutrition Radio. This is episode
0:18.2	385 of the podcast. My name is Danny Lennon.
0:22.6	I'm here with Alan Flanagan.
0:24.6	Alan, how are you today, sir?
0:26.6	I'm great. I'm good. I'm slowly getting back to normal.
0:29.6	What is it, day age, day nine now of into this study that I'm running at the minute.
0:36.6	So, so far, so good.
0:39.3	Great compliance from participants, which is wonderful.
0:41.3	Excellent. And yeah, you're still recruiting people for this study.
0:45.3	So maybe for people listening, because I'm sure there's a significant number
0:49.3	who are based in the UK from which you're going to be recruiting from,
0:52.3	can you first maybe mention what
0:55.3	the study is, but then for anyone who might be interested in becoming a participant, give them
1:00.6	any details there too? Yeah. So the study is looking at the relationship between meal timing and
1:09.6	someone's time of day preference. So people tend to either
1:12.7	have a preference for kind of being what's colloquially known as a morning type or a night
1:17.3	L. And there is also a relationship between that, your time of day preference, and what's known
1:25.8	as social jet lag lag which is maybe the
1:28.3	discrepancy between how much you get to sleep when you when you're free to choose your sleep
1:33.3	wake cycle versus how much you actually sleep when you have to get up for work and all this kind of
1:38.7	stuff so we're looking at the relationship between those factors and meal timing it's all observational
1:44.1	so there's no lab visits or anything, people completed at home using an app where it's very easy to use.
	...

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