#37: Lipids, PCSK9, and ezetimibe: Lower is better.
The Curbsiders Internal Medicine Podcast
The Curbsiders Internal Medicine Podcast
4.8 • 3.3K Ratings
🗓️ 1 May 2017
⏱️ 69 minutes
🧾️ Download transcript
Summary
Learn the latest in lipid lowering therapy in this extensive discussion with Dr. Paul S. Jellinger, MD, MACE, Professor of Medicine at the University of Miami and Chair of the writing committee for the American Association of Clinical Endocrinologists (AACE) 2017 Guidelines for the Management of Dyslipidemia and Prevention of Cardiovascular Disease (CVD). Topics include ezetimibe, PCSK9, FOURIER trial, statin myopathy, CoQ10, fish oil, fibrates and more. For a more basic discussion of dyslipidemia check out episode #10.
Full show notes are available at http://thecurbsiders.com/podcast
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Time Stamps
00:00 Intro
03:10 Rapid fire questions
08:15 Dyslipidemia defined
10:26 Classifying dyslipidemia
13:21 Diagnosing Familial Hypercholesterolemia
17:48 A difficult lipid case discussed
22:40 Lp (a), Apo B and LDL particle concentration
28:40 What labs to order
31:31 ACC/AHA versus other risk scores
38:21 IMPROVE-IT
41:35 Non-statin medications discussed
45:05 Hypertriglyceridemia fibrates and fish oil
48:25 How often to check the lipid panel
49:58 Statin Myopathy and CoQ10
54:17 FOURIER, PCSK9 and very low LDLs
59:43 Extreme risk category discussed
62:34 Is plaque regression possible?
64:12 Take home points
67:08 Outro
Tags: assistant, care, cholesterol, doctor, education family, fish oil, foam, foamed, health, hospitalist, hospital, internal, internist, ldl, lipid, medicine, medical, myopathy, nurse, pcsk9, physician, practitioner, primary, statin, resident, student
Transcript
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| 0:00.0 | Guys are a lot of fun by the you remind me of the frickin' fracked the the car guys |
| 0:07.0 | I think it's clicking crack. Thank you so much. That's a I'll take that as a highest compliment |
| 0:13.8 | I'll be frick |
| 0:15.8 | Welcome back to the curbsider. Hello the internal medicine podcast that uses expert interviews to bring you clinical pearls and practice changing knowledge |
| 0:34.6 | Definitely today. I'm Dr. Matthew Wato here with my co-host Dr. Stewart Brigham. Hello and Dr. Paul Williams |
| 0:42.0 | Hello, hey Paul. What's that? Paul you want to retry that hello? |
| 0:55.0 | Having an emotional moment here just give me some time. I'll be alright |
| 0:58.6 | Well, this was an emotional episode |
| 1:02.7 | Good emotions |
| 1:04.3 | We were talking about |
| 1:06.3 | Dislippidemia with our expert guest Dr. Paul S. Gellinger MD master of the American College of Endocrinology and he is also the chair or co-chair of the recent ACE |
| 1:20.4 | Dislippidemia guidelines which came out early in 2017 and had |
| 1:25.5 | created some a bit of a sterile by by targeting very low LDL goals, which we will talk about |
| 1:31.9 | He is a professor of clinical medicine in the division of endocrinology diabetes and metabolism at the University of Miami in May |
| 1:40.2 | 2004 he was a designated a master of the American College of Endocrinology a distinction that today has been awarded to only 45 |
| 1:48.6 | Endocrinologist nationally Dr. Gellinger is very active in ACE and has been involved in numerous publications related to diabetes |
| 1:56.2 | lipid disorders and other endocrin topics most recently he served as the chair of the writing committee for the recently published |
| 2:04.8 | 2017 ACE guidelines for the management of |
| 2:08.4 | Dislippidemia and prevention of cardiovascular disease |
| 2:11.9 | Which is why we're having him on the show tonight. So thank you to ACE for setting this up and without further ado |
| 2:18.5 | Here's our conversation with Dr. Paul S. Gellinger |
| 2:22.4 | Hello, and welcome back to the curbsider. Hey Matthew. Hi Stewart. Hey. This is your host Dr. Matthew Wato here with my co-host Dr. Stewart Brigham |
... |
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