#368: First-Pass Metabolism Explained: Key Insights for Nurses

Straight A Nursing: Study for nursing school exams & NCLEX

Straight A Nursing

Education, Medicine, Health & Fitness

4.6 • 1.2K Ratings

🗓️ 10 October 2024

⏱️ 17 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode, I'm breaking down the concept of first-pass metabolism, also known as the first-pass effect, and why it’s important for nurses to understand. You’ll learn how medications are metabolized, why bioavailability matters, and how the first-pass effect impacts drug dosing and effectiveness. We also discuss common medications affected by this process and how it influences the choice of administration routes. Listen to this episode and you’ll learn: What first-pass metabolism is - Get a brief overview of how PO medications are metabolized in the liver before reaching systemic circulation The basics of bioavailability - Learn how bioavailability measures how much of a drug reaches systemic circulation and why IV medications have higher bioavailability than oral medications. Some common medications affected by first-pass metabolism - Bring this concept to life with medication examples including nitroglycerine and diazepam. Nursing implications - Discover how understanding first-pass metabolism helps nurses administer medications effectively and why it impacts the timing of a drug's onset of action. ___________________ Full Transcript - Read the article and view references FREE CLASS - If all you've heard are nursing school horror stories, then you need this class! Join me in this on-demand session where I dispel all those nursing school myths and show you that YES...you can thrive in nursing school without it taking over your life! Study Sesh - Change the way you study with this private podcast that includes dynamic audio formats that help you review and test your recall of important nursing concepts on-the-go. Free yourself from your desk with Study Sesh! Straight A Nursing App - Study on-the-go with the Straight A Nursing app! Review more than 5,000 flashcards covering a wide range of subjects including Fundamentals, Pediatrics, Med Surg, Mental Health, Maternal Newborn, and more! Available for free in the Apple App Store and Google Play Store. Pharmacology Success Pack - Want to get a head start on pharmacology? Download the FREE Pharmacology Success Pack. Fast Pharmacology - Learn pharmacology concepts in 5 minutes or less in this audio based program. Perfect for on-the-go review! 💕Did you love this episode? Please take a moment to follow or subscribe to the show so you never miss an episode! ___________________ The information, including but not limited to, audio, video, text, and graphics contained on this podcast are for educational purposes only. No content on this podcast is intended to guide nursing practice and does not supersede any individual healthcare provider's scope of practice or any nursing school curriculum. Additionally, no content on this podcast is intended to be a substitute for professional medical advice, diagnosis or treatment. Straight a Nursing is a proud member of the Airwave Media Network. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	New York News is World News. So start your day off with the New York Daily News
0:05.8	podcast. Hear the latest coverage from the New York Daily News team all in just a few
0:10.7	minutes so you can get today's headlines whenever and wherever you are.
0:14.6	New episodes drop weekdays so listen and subscribe to New York Daily News wherever you get your
0:19.8	podcasts. That's New York Daily News, wherever you get your podcasts. Well, hi there I'm Nurse Mo and this is the Straight Day Nursing Podcast where I teach nursing concepts and share tips on how to thrive both in nursing school and at the bedside.
0:48.0	Today we have a short but powerful lesson covering a very important concept in pharmacology and that is the concept of first pass metabolism.
0:59.0	So if you've ever been a little bit stumped by this or maybe never heard of it. I want you to listen to this
1:05.8	episode. It will help you immensely. Before we do that, of course, I want to take a minute to thank
1:12.1	anyone who submits a review, submits feedback, and this listener shout out goes out to Amanda who says,
1:19.7	I love this podcast. Nurse Mo does such a great job of teaching about all
1:24.6	things nursing. Her Lauté method really helps me picture the clinical scenario
1:29.2	which helps me remember everything better.
1:32.5	NurseMose Podcast helps supplement my classes
1:35.2	so I can retain information better.
1:38.2	I love to listen while I make dinner
1:40.0	from my starving teenagers
1:41.5	and they appreciate that my need to study doesn't prevent them from eating.
1:46.0	Thank you, Nurse Mo.
1:47.0	Well, thank you, Amanda, for taking the time out of your very busy schedule to share your feedback and how much the podcast has helped you.
1:57.0	Alrighty, so we're talking today about First Pass metabolism. You may also hear this called the first pass effect and this is a
2:08.6	phenomenon that occurs as medication is metabolized by the body and essentially made less effective.
2:16.0	So in this episode we'll review the first pass effect and its implications for your nursing practice. Now to really understand the first pass effect or first pass metabolism,
	...

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