#330 GLP-1s. Everything You Need to Know | Ashley Koff, RD
The Doctor's Kitchen Podcast
Dr Rupy Aujla
4.8 • 2.5K Ratings
🗓️ 7 January 2026
⏱️ 120 minutes
🧾️ Download transcript
Summary
I don’t think GLP-1 meds are the answer for everyone, but I also don’t think they’re the villain of the story. For many people they can be genuinely life-changing, when they’re used with the right support. So this episode is for anyone who’s made that decision (or is seriously considering it) and wants to do it safely, sustainably, and with as much information as possible.
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I can’t stop you from taking these medications, but I can help you be informed: what to ask, what to monitor, what to eat, and how to protect your muscle, gut, and long-term health along the way.
Today’s episode is all about one of the biggest health conversations happening right now: GLP-1 medications.
I’m joined by Ashley Koff, RD, to give you the straight dope on what’s really going on beneath the surface: why so many of us are struggling with food noise, why some people never reach that “80% full” feeling, and what it means when your metabolic switches (the appetite and satiety systems that should be working in the background) aren’t firing properly.
We break down GLP-1s, starting with what happens in an optimally functioning body: the roles of hormones like GLP-1, GIP, PYY and CCK, and how they influence hunger, fullness, blood sugar, and cravings. We also talk through what side effects might be telling you, what to monitor if you do choose medication, and whether supplements have a role — including the so-called “GLP-1 boosters” you’ll see everywhere.
Most importantly, this episode is for anyone who wants lasting fat loss and better metabolic health, with or without drugs.
Ashley Koff is a registered dietitian and founder of the Better Nutrition Program, and she trains clinicians as course director for UC Irvine’s Integrative & Functional Medicine Fellowship. She’s also the author of the upcoming book ‘Your Best Shot’.
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Transcript
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| 0:00.0 | I don't think GOP1 medications are the answer for everyone. |
| 0:05.1 | But I also don't think that they're the villain of the story. |
| 0:08.3 | For many people, they can be genuinely life-changing when they're used with the right support. |
| 0:14.0 | So this episode is for anyone who's made that decision or is seriously considering it |
| 0:19.3 | and wants to do it safely and with as much |
| 0:22.5 | information as possible. |
| 0:26.6 | Hi, I'm Dr. Rupi. |
| 0:28.3 | I'm a medical doctor and nutritionist. |
| 0:30.7 | And when I suffered a heart condition years ago, I was able to reverse it with diet and lifestyle. |
| 0:36.1 | This opened up my eyes to the world of food as |
| 0:39.6 | medicine to improve our health. On this podcast, I discuss ways in which you can use nutrition |
| 0:45.9 | and lifestyle to improve your own well-being every day. I speak with expert guests and we lean |
| 0:51.5 | into the science, but whilst making it as practical and as easy as possible, |
| 0:56.1 | so you can take steps to change your life today. Welcome to the Doctor's Kitchen podcast. |
| 1:07.8 | I can't stop you from taking these medications, but I can help you be informed what to ask, |
| 1:14.1 | what to monitor, what to eat, and how to protect your muscle, gut and long-term health |
| 1:18.3 | along the way. Today's episode is all about one of the biggest health conversations |
| 1:24.0 | happening right now, and that's GOp1 medications and their sister medications as well |
| 1:29.4 | and so i'm joined by ashley coff she's a registered dietitian to give you the straight dope on |
| 1:35.2 | what's really going on beneath the surface why so many of us are struggling with something called |
| 1:40.9 | food noise why some people never reach that 80% full feeling. |
| 1:46.9 | And what it means when your metabolic switches, which are the appetite and satiety systems that |
... |
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