3. Supersoldiers and enhanced cognitive function with ketones! A conversation with Dominic D’Agostino, PhD
Paul Saladino MD podcast
Paul Saladino, MD
4.7 • 2.7K Ratings
🗓️ 23 July 2019
⏱️ 99 minutes
🧾️ Download transcript
Summary
Dr. Dominic D’Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, seizures, cancer and metabolic wellness. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations.
Time stamps
5:56 Nasa Neemo 23
17:38 Organization/entrepreneurship/ and prioritization.
19:38 Human Metabolism and the ketogenic diet.
29:07 Glucose Metabolism
31:06 Do we need glucose to run our body?
32:43 What changes in our body when we don't consume carbohydrates.
39:50 Medium chain triglycerides.
42:45 How do we adapt to ketosis?
44:52 Calorie restriction benefits of the ketogenic diet.
48:53 Neuro protective effects of ketones.
49:58 Anti-inflammatory mechanisms of ketones.
53:45 Histone deacetylase
56:40 Epigenome.
58:00 Krebs Cycle.
59:51 Mitochondrial Function with Ketones/oxidative stress.
71:17 Carbohydrate based metabolism and oxidative stress..
72:55 Mean amplitude glucose excursions.
76:10 Glucose, inflammation , oxidative stress and insulin resistance.
77:20 The Warburg Effect
89:35 Mitochondria Damage or nucleus damage in regards to cancer.
92:37 Ketogenic diet and Mitochondria protection.
94:20 The most radical thing Dom has done recently.
95:45 Where to find Dom online/upcoming projects.
Dom’s info:
Instagram: dominic.dagostino.kt
Twitter: DominicDAgosti2
Web: ketonutrition.org
Ancestral Supplements https://ancestralsupplements.com/ use the promo code “SaladinoMD” on the shopify site for 10% off.
JOOVV: www.joovv.com/paul
My contact information:
PATREON:
Transcript
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| 0:00.0 | Welcome to the Fundamental Health Podcast. |
| 0:08.2 | I'm your host, Dr. Paul Saladino. |
| 0:10.6 | This podcast is the result of my relentless search to understand and correct the roots |
| 0:14.7 | of chronic disease and illness. |
| 0:16.2 | In this podcast, I will share with you everything I have learned about how to live the most |
| 0:19.9 | healthy and radical life possible. |
| 0:22.3 | Thanks for joining me on this journey. |
| 0:26.8 | What's up everybody? |
| 0:27.8 | It's the middle of summer. |
| 0:28.8 | I guess it's the beginning of summer. |
| 0:29.8 | It's amazing. |
| 0:30.8 | I love it. |
| 0:31.8 | I'm out here in California digging it so much, surfing. |
| 0:34.3 | I just got out of the water. |
| 0:36.0 | The waves were not good, but I just got out of the ocean, which was pretty fantastic. |
| 0:39.7 | So now I'm recording this intro. |
| 0:41.5 | We're getting this podcast this week ready to roll. |
| 0:43.9 | My first question to you is, are you an insider? |
| 0:47.2 | Are you in the Cool Kids Club? |
| 0:48.4 | Go to my website, paulsaladinoemd.com, front slash insider. |
| 0:52.4 | Sign up for my insider. |
| 0:54.2 | It's a newsletter, but I call it an insider because that's really much cooler. |
... |
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