3.03 The National Lung Matrix Trial & the Major Flaw of the SPRINT Trial with Dr. Mark Friedberg

Plenary Session

Vinay Prasad, MD MPH

Health, Medicine, Policy, Oncology, Science & Medicine

4.7 • 789 Ratings

🗓️ 18 July 2020

⏱️ 69 minutes

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Summary

This week we discuss two major papers: The first was just recently released in Nature and it's titled "The National Lung Matrix Trial of personalized therapy in lung cancer". The second is a few years old, but exemplifies the importance of trial design. We discuss the second paper, titled "A Randomized Trial of Intensive versus Standard Blood-Pressure Control" and published in the New England Journal of Medicine with Dr. Mark Friedberg, a health policies and performance measurement researcher. National Lung Matrix Trial: doi.org/10.1038/s41586-020-2481-8 SPRINT: doi.org/10.1056/NEJMoa1511939 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Transcript

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0:00.0	Welcome. I'm Dr. Vinay Prasad. I'm a hematologist, oncologist, and I'm associate professor of medicine at the University of California, San Francisco. In my professional life, I see patients, I teach trainees, and I do research in health care policy. This is plenary session.
0:22.9	Plenary session is a podcast at the intersection of medicine, oncology, and health policy.
0:27.5	And you're listening to Season 3.
0:30.6	On this week's episode.
0:33.1	I am going to discuss the National Lung Matrix Trial of Personalized Therapy and Lung Cancer,
0:37.8	the new nature paper that's out this week.
0:40.4	You won't want to miss that.
0:41.6	And then I'm joined via Zoom by Dr. Mark Friedberg, and we're going to be talking about the Sprint trial.
0:46.6	Yes, you may have forgotten about Sprint.
0:48.5	But Mark's going to explain why trial design is oh so important,
0:52.1	and he's going to point out something that has been glossed
0:54.9	over many, many times. So, stay tuned.
0:58.5	If you like this podcast and want more content, follow me on Twitter at Viprasad MDMPH.
1:05.0	Check out the YouTube channel, Vinayprasad MDMPH.
1:09.2	Patreon backers will get access to the slides for lectures I give on plenary session.
1:13.8	Want to hear from us?
1:15.0	Email us your question at plenary session podcast at gmail.com.
1:35.1	First of First up, the National Lung Matrix Trial of Personalized Therapy and Lung Cancer.
1:38.8	This is the paper that appeared on July 15th in nature.
1:41.3	What do I want to say about this paper?
1:45.8	Well, people who follow me on Twitter will know I spent a great deal of time with this paper because I tried to summarize it in a single slide, and I tweeted that out.
1:50.0	And that tweet has gotten 55 retweets and 100 and some odd likes, so maybe people find it interesting.
	...

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