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The Economics of Everyday Things

28. Horseshoe Crab Blood

The Economics of Everyday Things

Freakonomics Network

Business

4.81.6K Ratings

🗓️ 6 April 2026

⏱️ 14 minutes

🧾️ Download transcript

Summary

How does the blood of a 450-million-year-old arthropod help prevent lethal infections in humans? And could we exhaust the supply? Zachary Crockett wades in. This episode was originally published on December 10th, 2023.

Transcript

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0:00.0

Every year in late spring, America's Atlantic coastline hosts one of the animal kingdom's wildest orgies.

0:17.0

The sandy shores are taken over by thousands of horseshoe crabs who mate and lay clusters of eggs.

0:25.2

This feverish lovemaking might be part of why the species is so resilient.

0:31.9

Horseshoe crabs have been around for around 450 million years.

0:37.2

They were here before the dinosaurs

0:38.7

and survived a mass extinction

0:40.9

that wiped out 90% of life on Earth.

0:46.0

But lately, a new species has joined the party.

0:50.2

Humans.

0:51.5

Humans who are quite literally out for the horseshoe crab's blood.

0:56.7

They have this somewhat magical blood. It's used to do a lot of our pharmaceutical testing,

1:03.4

everything from COVID vaccines to insulin to any injectable medications that we use on our day-to-day basis.

1:15.2

Horseshoe crab blood has been called the medical equivalent of gold.

1:19.6

By one estimate, it's worth around $60,000 a gallon.

1:24.0

And the growing market for it is at the center of an ethical debate between environmentalists and

1:29.7

biomedical firms.

1:31.9

For the Freakonomics Radio Network, this is the economics of everyday things.

1:36.7

I'm Zachary Crockett.

1:38.3

Today, Horseshoe Crab Blood.

1:41.7

To better understand how Horseshoe Crab Blood became such a valuable commodity, I turned to an expert.

1:49.2

I'm Dina Fine Marin. I'm the senior reporter that covers wildlife crime at National Geographic.

1:55.0

Marin has spent her career looking into all kinds of offenses, rhino horn trafficking, dinosaur fossil heists, even leech smuggling.

...

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