#27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 5 November 2018

⏱️ 101 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode, David A. Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, provides insight into why we age and how to slow its effects based on his remarkable work on the role of sirtuins and NAD in health and diseases. He also presents the case that stabilizing the epigenetic landscape may be the linchpin in counteracting aging and disease.

We discuss:

How and why David moved from Australia to Leonard Guarente’s lab at MIT [7:30];
Sirtuins and aging [15:00];
A series of experiments elucidating the mechanisms of sirtuins [20:45];
How are sirtuins activated? [25:30];
NAD and sirtuin activation [31:00];
Nicotinamide, sirtuin inhibition, andPNC1 [39:00];
Resveratrol [43:00];
The NIH/ITP studies on resveratrol [55:45];
Does David take any compounds for longevity? [1:00:15];
NAD precursors (NR, NMN) and pterostilbene [1:02:45];
Female fertility and NAD precursors [1:14:45];
A unifying theory of aging [1:20:30];
Waddington’s epigenetic landscape [1:23:00];
If David had unlimited resources, what is the experiment he would do? [1:28:25];
Testing combinations to extend lifespan [1:31:30];
What made David aware of his mortality at such a young age? [01:33:45];
What is David’s book going to cover? [01:37:15]; and
More.

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Transcript

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0:00.0	Hey everyone, welcome to the Peter Atia Drive. I'm your host, Peter Atia.
0:10.0	The drive is a result of my hunger for optimizing performance, health, longevity, critical thinking,
0:15.7	along with a few other obsessions along the way. I've spent the last several years working
0:19.6	with some of the most successful top performing individuals in the world, and this podcast
0:23.8	is my attempt to synthesize what I've learned along the way to help you live a higher quality
0:28.3	and more fulfilling life. If you enjoy this podcast, you can find more information on today's
0:32.5	episode and other topics at peteratiamd.com.
0:41.6	Hi everyone, welcome to this week's edition of the Peter Atia Drive. I'm Peter Atia. This week,
0:48.4	my guest is Professor David Sinclair. He's a professor in the Department of Genetics at Harvard
0:54.3	Medical School, and he is the co-director of the Paul F. Glenn Center for the biological mechanisms
1:01.9	of aging. David Hales from Australia, that'll take you about 10 seconds into our interview to
1:06.6	figure out. He did his PhD in molecular genetics at the University of New South Wales in Sydney,
1:12.0	and it was at that time that he met the man that would go on to become his mentor. We talk a lot
1:16.7	about him and this is a guy Lenny who's actually come up on other podcasts so I won't get into him
1:21.5	now, but nevertheless David met Lenny and decided he wanted to come to MIT to study with him,
1:27.0	which is what he did. David has gone on to become one of the pioneers in a particular field of aging
1:34.0	that focuses on a class of molecules known as sirtuans. I'm sure many of you have heard of sirtuans,
1:41.9	but you might not entirely be clear on what sirtuans are. I won't obviously make any attempt to do
1:46.9	that here in the intro because we spend so much time talking about that during this episode.
1:51.9	The other thing that David is really quite famous for is his role in the discovery of a molecule or
1:58.6	class of molecules that stimulate sirtuans, and by the time you get through this episode, you will
2:02.6	understand why that may be a desirable thing to do, and among these the most famous is one called
	...

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