#264: Prof. Michael Ristow – Longevity, Mitochondria & Free Radicals

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 22 January 2019

⏱️ 45 minutes

🔗️ Recording | iTunes | RSS

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Summary

Links:

About This Episode:

Role of mitochondria in lifespan regulation and prevention of metabolic diseases
Health-promoting effects associated with: low caloric intake, reduced glucose metabolism, physical exercise, sirtuin signaling & more
How Prof. Ristow’s findings go against the popular “free radical theory of aging”
How increased formation of reactive oxygen species (ROS) within mitochondria can increase longevity
ROS causing a vaccination-like adaptive response that culminates in increased stress resistance and extended longevity
Mitochondrial hormesis or mitohormesis
Human vs. non-human trials
How do insulin, protein and resveratrol affect longevity?
NAD
Caloric restriction vs maintenance of lean physique for longevity

Head of Institute of Translational Medicine at ETH Zurich and heads up the Energy Metabolism Laboratory. Prof. Ristow has been involved in research for many years examing Biochemistry and Physiology of Aging, Exercise, Obesity, Type 2 Diabetes.

Prof. Ristow’s group are interested in the biochemical and molecular basis of longevity — in particular the role played by mitochondria in lifespan regulation and prevention of metabolic diseases. Contrary to the widely re-iterated ‘Free Radical Theory of Aging’, his group have been the first laboratory to show that the health-promoting effects associated with low caloric intake, physical exercise and other lifespan-extending interventions like sirtuin signaling are caused by increased formation of Reactive Oxygen Species (ROS) within the mitochondria, causing a vaccination-like adaptive response that culminates in increased stress resistance and extended longevity, a process called mitohormesis.

Transcript

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0:00.0	So exposing an organism to low non-lethal doses of a potentially toxic compound, toxic in the sense of higher doses will become toxic,
0:18.0	low doses do not, is initiating a vaccination-like response.
0:23.6	So the organism gets primed to unwanted external measures and is better prepared to fight back
0:31.6	such attacks. And this also applies to free radicals that are produced within the organism.
0:42.6	So repeated exposure to low doses of free radicals within the organism,
0:47.7	primes the organism to be better prepared to higher external cues the organism. Hello and welcome to another episode of Sigma Nutrition Radio.
1:00.6	You are very welcome.
1:02.0	I am your host, Danny Lennon, and we're at episode 264 of the podcast today.
1:09.3	And just before we get into things, a couple of things to note. First of all,
1:14.6	for those of you down in Australia, as I've mentioned previously on the podcast, over the coming
1:20.6	months, I'm going to be doing a number of different seminars and speaking at a couple of different
1:24.7	conferences in various cities around Australia.
1:27.9	So if you want to get information about any of those, the different types of events going on,
1:32.7	then they'll all be up on sigmautrition.com.
1:35.4	If you navigate there, then in the menu, it'll be pretty easy to find the seminar list for Australia.
1:41.1	But essentially, I'll be doing a body composition workshop for coaches along
1:46.4	with the guys from JPS will be in Melbourne, Ballarat, Sydney, Wallingong, Gold Coast,
1:54.0	Perth and possibly elsewhere and I'll also be speaking at the ISSN conference in Gold Coast
2:00.3	in the middle of February and at the ultimate evidence-based conference in Melbourne this June.
2:05.7	So all of that I will link up to information at sigmautrition.com.
2:10.2	And hopefully you guys can get to one or multiple of those events.
2:14.6	And I hope to meet you there.
	...

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