#24 - Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 19 October 2018

⏱️ 90 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject of lipids. In Part V, Peter and Tom talk about inflammation, endothelial health, and oxidative stress as they pertain to cardiovascular disease, and our attempts to monitor them using biomarkers. They also discuss a couple of very important risk factors that too few people (and doctors) know about. Tom closes the five-part series with a tragic story about his good friend that is likely all-too-common for many practicing physicians, that both haunts and motivates Dr. Dayspring to learn as much as he can about the number one killer in the United States.

We discuss:

Lp(a) [2:30];
Inflammation [17:15];
Oxidative stress markers: Lp-PLA2 and oxLDL [20:45];
Endothelial health markers: ADMA and SDMA [34:30];
Remnants [43:45];
Omega-3 fatty acids (EPA and DHA) and apoC-III [55:30];
Red blood cells and cholesterol transport [1:07:45];
Tom's friend Earl [1:10:00];
Peter's friend JP [1:18:15]; and
More.

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Transcript

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0:00.0	Hey everyone, welcome to the Peter Atia Drive. I'm your host, Peter Atia.
0:10.0	The drive is a result of my hunger for optimizing performance, health, longevity, critical thinking,
0:15.7	along with a few other obsessions along the way. I've spent the last several years working
0:19.6	with some of the most successful top performing individuals in the world, and this podcast
0:23.8	is my attempt to synthesize what I've learned along the way to help you live a higher quality
0:28.3	more fulfilling life. If you enjoy this podcast, you can find more information on today's
0:32.4	episode and other topics at peteratiamd.com.
0:36.1	Hi everybody, welcome to the fifth and final episode in the week of Tom. This is the tour
0:48.2	de force magnum opus course on lipidology. As we round this out, we talk about a number of
0:54.5	things. We talk about LP little a inflammation oxidized LDL remnants red blood cells and cholesterol,
1:03.2	a biomarker called LP PLA2 that you've often probably heard about. Another biomarker that
1:08.3	you may have not heard of called ADMA or asymmetric dimethylarginine and SDMA, symmetric dimethylarginine.
1:15.8	And then we kind of bring it back to what is one of the more tragic stories in Tom's life,
1:20.8	which is a friend of his who unfortunately probably had FH wasn't treated. And in many
1:27.2	ways is sort of one of those patients that still kind of haunts Tom. And I think, you know,
1:32.0	we open this back in part one by talking about Tom's passion for two other things, firefighting
1:38.1	and hockey and how that passion is what really got him into or basically allowed him to
1:44.2	apply himself to this new field once he became obsessed. But also I think most physicians
1:49.6	listening to this will have a similar story where there are certain patients or there are
1:53.0	certain personal relationships where a loss of life stays with you for a very long period of time.
1:58.1	And in many ways it colors what you do over time. So I hope you enjoy this fifth and final
2:03.5	installment of the lipidology advanced course. And next week we'll be back to our regular
	...

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