23 - The truth about GLP-1s, weight loss and nutrition with Dr Jack Mosley

The Dr Louise Newson Podcast

Dr Louise Newson

Health & Fitness, Mental Health, Medicine

4.8 • 798 Ratings

🗓️ 2 September 2025

⏱️ 32 minutes

🔗️ Recording | iTunes | RSS

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Summary

GLP-1 medications such as Ozempic, Wegovy and Mounjaro have become some of the most widely discussed weight loss treatments in the world. They were once mainly talked about in medical research, but now they’re a regular feature in celebrity culture, weight loss headlines and even major advertising campaigns, including one recently fronted by Serena Williams.

But beyond the endorsements and headlines, what do we really know about these drugs? How effective are GLP-1 weight loss medications, what risks and side effects should be considered, and how should they fit alongside approaches like nutrition, exercise and hormone balance?

In this episode, Dr Louise Newson is joined by Dr Jack Mosley, GP registrar, author and son of the late Dr Michael Mosley. They explore the science, benefits and limitations of GLP-1s, why weight management remains such a challenge, and how lifestyle and medical treatments can complement one another.

Jack also reflects on his father’s legacy and offers his own perspective on where medicine is heading. It’s a thoughtful and wide-ranging discussion that brings clarity to one of the most high-profile debates in health today.

Don’t forget, the Dr Louise Newson Podcast has been nominated in the British Podcast Awards. You can vote here: https://www.britishpodcastawards.com/voting

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Transcript

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0:00.0	Some of you might know already, but this podcast has been nominated by the British podcast awards
0:06.0	for the listeners' choice. So we really need your votes because it would be such an honour and
0:11.7	thrill to do well in this. So if you go to the show notes and click on the link, it won't take you
0:17.0	long. Please just vote for us. Thank you so much. On my podcast today, I've got Dr Jack
0:25.8	Mosley, who's a GP registrar and an author. He's also the son of the late Dr Michael Mosley.
0:32.9	We have a conversation about nutrition, about GLP-1s, what they're good at doing and what perhaps
0:38.5	they're not so good at doing. And we talk about fat, the role of fat, how it can be detrimental
0:43.8	for our future health and also obviously talk about hormones. So it's a great conversation.
0:49.6	I hope you enjoy it.
0:53.3	So Jack, great that you're here from Manchester, which makes me feel very nostalgic because
0:59.1	I spent many a happy year in Manchester.
1:02.5	And actually, you did some of your GP training where I did my GP training, so small world.
1:08.4	Yeah, thank you so much for having me.
1:09.9	And like you were saying, we've worked in some of the same hospitals,
1:13.7	some of the same GP practices as well.
1:16.6	Yeah.
1:16.9	Which is very interesting.
1:18.4	But you know, medicine's really changed.
1:19.9	So it was 25 years ago that I became a GP.
1:23.8	And, you know, we didn't, we had a bit of obesity, but not much.
1:29.0	The NHS was not on its knees as it is now.
1:32.8	It was, we were really, we've always been really holistic in our care.
	...

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