#214 COVID Cakes 3: Llamas, Remdesivir, Strokes, Predicting the Future, and More!

The Curbsiders Internal Medicine Podcast

Health & Fitness, Medicine, Science, Higher Education, Education

4.8 • 3.1K Ratings

🗓️ 18 May 2020

⏱️ 52 minutes

🔗️ Recording | iTunes | RSS

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Summary

Elevate your critical appraisal skills as we review the first RCT of remdesivir and share the latest and greatest COVID-19 stories including: Llama antibodies, Stroke statistics, Future Waves, Exit Strategies and Awake Proning. We’re joined by everyone’s favorite Curbsider/internist/epidemiologist, Rahul Ganatra MD MPH (@rbganatra). Rahul provides critical appraisal of the newest randomized control trial (RCT) on remdesivir from the Lancet, and gives us a lesson on why statistical power is so important to consider. We also share updates on strokes, awake proning, pandemic predictions, and we reveal another reason to love llamas (besides those luscious lashes). Llama mia, here we go again!

Credits

Written and Produced by: Sarah P. Roberts MPH, Rahul Ganatra MD, MPH, Emi Okamoto MD, Paul Williams MD and Matthew Watto MD
Cover Art: Beth Garbitelli
Hosts: Matthew Watto MD, Paul Williams MD, Rahul Ganatra MD MPH, Emi Okamoto MD , Sarah P. Roberts MPH,
Editor: Matthew Watto MD (written materials); Clair Morgan of nodderly.com

Sponsor: VCU Health CE

Time Stamps

00:00 Intro
02:10 Fun animal facts: Llama antibodies
09:10 Remdesivir RCT by Wang et al
12:40 Power and Sample Size
16:32 Baseline Characteristics, Results and Author’s conclusions
19:15 Rahul’s conclusions: How chance and bias affected the results
24:00 Right censoring; Viral load and timing of antivirals
30:30 Final thoughts on Remdesivir RCT by Wang et al; Looking ahead to the NIAID (ACTT) trial
33:53 Are patients really having fewer strokes and heart attacks?
38:20 Awake proning
43:30 Paul teaches us not to use the term “happy hypoxemic”
45:00 CIDRAP viewpoint on future waves and exit strategies
50:22 Outro

Transcript

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0:00.0	The Curbsiders podcast is for entertainment, education, and information purposes only, and
0:07.0	the topics discussed should not be used solely to die in a street cure or prevent any diseases
0:09.7	or conditions.
0:10.7	For the more the views and statements expressed on the podcast are solely those of those,
0:12.2	and should not be interpreted to reflect the official policy or position of any entity
0:14.4	that's either on the possibly, cash like more hospital and affiliate outreach programs.
0:16.8	If indeed there are any, in fact there are none.
0:18.6	Pretty much we aren't responsible if you screw up, you should always do your own homework
0:20.4	and let's know when we're wrong.
0:30.8	Well everybody, this has been quite a night, Paul.
0:36.9	What do you think is happening?
0:38.4	Is this really Y2K as Rahul suggested?
0:41.5	Well I think the year is not correct for that.
0:44.2	I'm a couple of years after the millennium, right?
0:48.3	Yeah, I'm but a country doctor, but somehow I don't feel like the math lines up for me,
0:51.7	but I'll believe anything at this point.
0:53.5	Right.
0:54.5	So this is the Curbsiders.
0:55.5	This is our I think third COVID Cakes episode.
0:58.6	We have a great show tonight featuring the great Rahul Ganatra and some critical appraisal,
1:04.6	our good friend Emmy Okamoto, and of course our fearless producer of Sarafibee Roberts.
1:10.6	They're going to introduce themselves and they'll be talking in a bit here, but first
	...

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