#206 Eosinophilia: 5 Pearls Segment
Core IM | Internal Medicine Podcast
Core IM Team
4.8 • 1.2K Ratings
🗓️ 27 April 2026
⏱️ 44 minutes
🧾️ Download transcript
Summary
Can you distinguish benign eosinophilia from a sign of serious disease, and know exactly when to act at the bedside?
In this high-yield episode, test your clinical reasoning as we tackle:
- When eosinophilia becomes dangerous and why it matters
- How to distinguish if its from atopy vs. systemic disease
- Which medications to stop (and which to watch)
- How travel, diet, and exposure history shape your workup
- When to suspect malignancy before giving steroids
02:34 | Why Do We Care About Eosinophilia? (Pearl 1)
10:24 | Atopy and Eosinophilia (Pearl 2)
18:57 | Drugs and Eosinophilia (Pearl 3)
27:29 | ID and Eosinophilia (Pearl 4)
33:54 | Pearl 5: Eosinophilia, Steroids, and Neoplasms (Pearl 5)
Tags: CoreIM, Internal Medicine, Medical Education, Eosinophilia, Hypereosinophilia, Allergy Immunology, Hematology, Pulmonology, Parasitic Infections, Atopy
Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840
Our Sponsors:
* Check out Branch Basics and use my code branchbasics.com/COREIM for a great deal: https://branchbasics.com
* Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com
* Check out Quince for high-quality clothes with affordable pricing and use code quince.com/coreim
Advertising Inquiries: https://redcircle.com/brands
Privacy & Opt-Out: https://redcircle.com/privacy
Transcript
Click on a timestamp to play from that location
| 0:00.0 | I think one has to be vigilant that on occasion this curious cell can indeed contribute to and cause tissue damage. |
| 0:10.0 | And it's up to us to be cognizant of that risk, evaluate appropriately to try to determine that risk, and then ameliorate it in intelligent and rational manner if we can. |
| 0:24.4 | Welcome to the Choram Thigh Pearls podcast, bringing you high-yield evidence-based pearls. |
| 0:29.2 | I'm Dr. Shred Chavetti, and I'm joined by... |
| 0:31.3 | Hi, I'm Gila Gershian, an internal medicine resident at Beth Israel Deaconess Medical Center. |
| 0:36.2 | Today's episode is all about peripheral eocinophilia. |
| 0:39.7 | Yes, and to help us sort through this, we spoke to experts in the world of allergy and |
| 0:43.8 | immunology, hematology, and pulmonology, and to dig into this topic in a way that I'm biased, |
| 0:49.5 | but I feel like, is way more approachable than what I knew before. Agreed. |
| 0:56.7 | Hi, I'm Dr. Peter Weller, Chief of the Allerty Division and the former chief of the ID Division at the B.I Deaconess. I've had a long-standing |
| 1:04.1 | interest in ESS. Enophilia. Hi, I'm Jason Freed. I'm a hematologist at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston. |
| 1:13.6 | I'm Trevita Cothoda from Pulmonary Critical Care at University of California, San Diego. I'm a professor of medicine there. I have a practice that focuses on esophobic diseases. |
| 1:24.6 | And as always, please pause after each of the following pearls and test yourself. |
| 1:30.1 | Because the more you test yourself, the deeper you're learning games. |
| 1:37.3 | Pearl 1. Threshold and why we care. |
| 1:39.8 | Why do we care about eosinophilia and when does the Eocinophilia become dangerous? |
| 1:47.7 | Pearl 2. |
| 1:48.9 | Eocinophilia and A2P. |
| 1:50.4 | When can asthma, allergic rhinitis or eczema explain eosinophilia? |
| 1:54.2 | And when should you worry something more systemic is going on? |
| 2:00.8 | Pearl 3. Medications. Which medications most likely cause eosophilia, and when is it safe to monitor versus when you need to stop? |
| 2:13.3 | Pearl 4. Infections and parasites. How do travel, immigration history, and diet guide your infectious workup? And finally, Pearl 5. Steroids and malignancy. How does steroids affect that eosinphal count? And why do we need to think about neoplastic causes of eosinophilia before we treat? |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Core IM Team, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Core IM Team and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2026.