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Core IM | Internal Medicine Podcast

#202 Dementia Part 2: Gray Matters Segment

Core IM | Internal Medicine Podcast

Core IM Team

Education, Mental Health, Health & Fitness, Medicine

4.81.2K Ratings

🗓️ 12 March 2026

⏱️ 48 minutes

🧾️ Download transcript

Summary

Most clinicians see dementia medications on the med rec, but many of us aren’t sure how much they actually help. In this episode we break down donepezil, memantine, and the new anti-amyloid drugs, and when to stop them.

• Do cholinesterase inhibitors really work?

• What should clinicians know about lecanemab and donanemab before referring patients?

• How much benefit should we expect and for how long?

• When should you deprescribe dementia medications?


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🔹Transcript and Shownotes

02:27 | Deep Dive 1: How do we deliver the news of a diagnosis of dementia?

09:41 | Deep Dive 2: Prescribing medications for cognitive decline

29:30 | Deep Dive 3: Patient-centered management for a patient with cognitive decline

35:46 | Deep Dive 4: Planning for an uncertain future


Tags: CoreIM, Internal Medicine, Medical Education, Cognitive Screening, primary care, nurse practitioner, physician assistant



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Transcript

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purchase. And with that, let's head back to the episode. The following is meant to be for medical

1:09.5

education and not formal

1:10.9

medical advice. Remember to always consider the patient in front of you, especially with

1:14.6

matters as gray as these. The views expressed in this episode don't reflect the views of any

1:18.9

affiliated institutions. Welcome back to gray matters, where we unpack how medical management

1:24.9

is rarely black or white. And go on lots of deep dives along the way.

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