#20 Vancomycin: Mind the Gap Segment

Core IM | Internal Medicine Podcast

Core IM Team

Mental Health, Education, Health & Fitness, Medicine

4.8 • 1K Ratings

🗓️ 1 August 2018

⏱️ 14 minutes

🔗️ Recording | iTunes | RSS

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Summary

Lets go deeper into the misunderstood side of Vancomycin! * Where did vancomycin come from, and why is it so controversial? (0:28) * What is vancomycin-induced nephrotoxicity and how common is it? (4:37) * Vancomycin trough monitoring – what is it good for? (7:28) * AUC to MIC ratio – the real math behind vancomycin dosing (7:53) * Review of teaching points (10:27) Full show notes: https://www.coreimpodcast.com/2018/08/01/mind-the-gap-vancomycin/ (https://www.coreimpodcast.com/2018/08/01/mind-the-gap-vancomycin/) Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy

Transcript

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0:00.0	It reads like something out of an Indiana Jones story.
0:07.0	A nerdy Indiana Jones story.
0:10.0	Work with me here.
0:11.0	The journey we're about to head off on centers on a sudden discovery, a
0:15.6	fade tenanimity and a story of redemption. Oh I like that. Redemption stories are
0:20.5	the best. Classics like on the waterfront, Dumb and Dumber.
0:24.4	Dumb and Dumber is a classic.
0:26.4	The year is 1952.
0:28.6	Fade into the wild, unkempt rainforest of Borneo.
0:31.9	A missionary is scooping up samples of dirt.
0:34.1	Okay, this is kind of cool. I'm with you.
0:36.0	This seemingly ordinary cup of dirt has a secret in it. A bacteria misidentified as a fungus.
0:41.9	A mycolatopsis Orientalis.
0:44.7	Overhead, a plane flies out of the jungle.
0:46.8	Carrying it to the exotic, distant Eli Lilly and company wraps.
0:51.6	What?
0:52.0	You've lost me again. Hidden in this cup is a drug, perhaps
0:55.4	now one of the most famous antibiotics in medicine. It's a small molecule that
1:00.0	curiously kills off Staphylococcus. After purification, it was called, no joke, the Vancher.
1:05.8	Like a bad Marvel comic superhero.
1:08.0	But you probably know it by its generic name.
1:10.2	When it came to market, the Don Drapers of the world combined
	...

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