19. Can we live forever? A conversation about aging with David Sinclair PhD
Paul Saladino MD podcast
Paul Saladino, MD
4.7 • 2.7K Ratings
🗓️ 5 November 2019
⏱️ 113 minutes
🧾️ Download transcript
Summary
David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.
Time stamps:
9:35 Start of podcast.
10:53 Does when you eat matter more than what you eat?
12:48 Time restricted feeding and longevity.
17:04 What causes us to age?
20:05 What cellular information is being lost?
26:35 What Causes DNA break?
28:47 DNA breaks as clastogenesis.
29:32 Food and DNA breaks
31:28 PARP enzymes.
34:57 NAD
40:15 NAMPT
42:35 Nicotinamide and sirtuins.
44:25 Methylation and methyl groups.
45:44 Sirtuins.
48:11 Heat/cold and sirtuins/NAMPT
52:54 What do sirtuins do with ADP ribose.
56:15 Role of active sirtuins.
58:25 Other longevity genes.
1:04:30 Importance of mitochondrial NAD levels.
1:05:50 Ketosis and NAD.
1:11:20 Resveratrol.
1:14:45 Xenohormesis and plant molecules- my view vs David’s
1:19:55 Resveratrol trials, concerns about resveratrol.
1:26:05 mTOR
1:31:37 David's plant based diet- and why it could be better
1:38:10 Meat consumption and the environment
1:45:35 Where to find David's stuff.
1:47:20 The most radical thing David has done recently.
David’s contact info:
https://genetics.med.harvard.edu/sinclai
Transcript
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| 0:00.0 | Welcome to the Fundamental Health Podcast. |
| 0:08.2 | I'm your host, Dr. Paul Saladino. |
| 0:10.6 | This podcast is the result of my relentless search to understand and correct the roots |
| 0:14.7 | of chronic disease and illness. |
| 0:16.3 | In this podcast, I will share with you everything I have learned about how to live the most |
| 0:19.9 | healthy and radical life possible. |
| 0:22.4 | Thanks for joining me on this journey. |
| 0:26.9 | What is up you guys? |
| 0:28.3 | So many of you have been asking for this episode. |
| 0:31.0 | I am so happy to share my conversation with none other than David Sinclair. |
| 0:36.7 | He is a PhD geneticist. |
| 0:38.6 | He's a professor in the Department of Genetics at this little university in Boston called |
| 0:42.8 | Harvard. |
| 0:43.8 | Obviously, that's a joke. |
| 0:45.6 | He is really prolific in this field. |
| 0:47.6 | He recently wrote the book Life Span and has been at the forefront of much of the research |
| 0:54.2 | pushing our understanding of human aging, how to avoid it, Sir Tuen's NAD. |
| 0:59.6 | We talk about all of it in this podcast. |
| 1:01.8 | So I think you guys are really, really going to be stoked about this one. |
| 1:07.4 | Like I said, he really needs new introduction. |
| 1:10.3 | If you are not aware of him, then you should learn a ton from this podcast. |
| 1:18.1 | We go into a lot of detail. |
... |
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