#169 MGUS to Multiple Myeloma Diagnostics and Counseling: 5 Pearls Segment

Core IM | Internal Medicine Podcast

Core IM Team

Mental Health, Education, Health & Fitness, Medicine

4.8 • 1K Ratings

🗓️ 22 January 2025

⏱️ 56 minutes

🔗️ Recording | iTunes | RSS

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Summary

SPEP vs. UPEP? What does it tell you and not tell you? What is the role for immunofixation and free light chains in diagnosis? Learn about paraneoplastic antibodies with MGCS and its renal, neurologic, and dermatologic manifestations!

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Transcript and Show Notes

Timestamps:

(01:26) | Pearl 1: What is a monoclonal gammopathy? What is our expected clinical presentation?

(10:12) | Pearl 2: What is our initial workup? Understanding SPEP, Immunofixation, and Free Light Chains

(24:13) | Pearl 3: Do we need urine testing? When urine testing is necessary and when it is not.

(26:26) | Pearl 4: How should we differentiate monoclonal gammopathies? The continuum of MGUS, SMM, and MM.

(41:35) | Pearl 5: Demystifying Monoclonal gammopathy of clinical significance (MGCS)

Tags: CoreIM, Internal Medicine, ClinicalPearls, Medical Education, IMCore, hospitalist, physician assistant, nurse practitioner, medical student, internal medicine

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Transcript

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0:00.0	A quick word from our sponsor, Freed. If you're looking to streamline your workflow,
0:04.3	Freed is an AI scribe designed to help you do just that. Freed will listen, transcribe, and
0:09.7	draft your note all the while being fully HIPAA compliant. I've been using Freed regularly
0:15.6	on my shifts and I do have to say it is really user-friendly. It seamlessly integrates into my workflow on the phone
0:22.2	and on the computer. I've also really appreciated how it really adapts to my style of note writing.
0:27.6	I think we all have our unique ways we like our notes to be. For what it's worth, I think can be
0:32.4	a huge game changer in making all our days feel a bit more manageable. And you can also use the code Core 50 to get
0:39.2	$50 off your first month of Freed. Again, that's Core 50 for $50 off your first month of
0:46.0	free. So give it a try and see how an AI scribe can make a difference in your day. And with that,
0:52.1	let's get into the episode.
0:55.0	Welcome to the Koriam,
0:56.2	by Pearls podcast.
0:57.3	This is Dr. Shreya Trevedi.
0:59.2	Hello, I'm Dr. Nate Long,
1:00.9	a senior resident at BIDMC.
1:03.5	Let's get started with the Pearls
1:04.7	we'll be covering today.
1:05.9	Be sure to test yourself
1:06.9	by pausing after each of the five questions.
1:09.9	Remember, the more you test yourself,
1:11.8	the deeper your learning gains. Pearl number one, clinical presentation of monoclonal gamopathies.
1:18.9	How common are monoclonal gamopathies and what are the typical illness groups?
	...

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