#160 - Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variants

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 3 May 2021

⏱️ 86 minutes

🔗️ Recording | iTunes | RSS

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Summary

Paul Offit is a pediatrician specializing in infectious diseases and an expert in virology and vaccine development. He currently serves on the FDA committee evaluating COVID-19 vaccines. In this episode, Paul’s second appearance on The Drive, he provides an update on all the SARS-CoV-2 vaccines currently deployed, explains why the concerns raised around the mRNA vaccines are not legitimate, and offers his view on the prospects and timeframe of reaching herd immunity. He also takes a deep dive into immunology, explaining the short-term and long-term immune response to both natural infection and vaccination and how these two can function together to provide durable immunity. Additionally, they discuss the theories on the origins of this virus, what impact the new COVID-19 variants might have, and the recent pausing of the J&J vaccine. Finally, they discuss how we can be better prepared for an inevitable future outbreak of a novel virus. This episode was originally recorded on April 14, 2021.

We discuss:

Overview and current status of the SARS-CoV-2 vaccine strategies [4:10];
Addressing concerns about mRNA vaccines [9:00];
How the failure to make an effective HIV vaccine aided the development of a COVID-19 vaccine [16:45];
Where SARS-CoV-2 falls on the spectrum of its ability to mutate and what that means for immunity and vaccination [21:30];
How the combination of short-term and long-term immune response to SARS-CoV-2 work together to provide durable immunity [28:00];
Importance of understanding relative vs. absolute risk reduction [38:15];
Implications of pausing the J&J vaccine due to reports of blood clotting in the brain [42:45];
What constitutes herd immunity and the concerns of rising vaccine hesitancy [47:45];
When we might reach herd immunity, future vaccines for children, and long-term outlook for maintaining population immunity [58:45];
Theories about the origins of SARS-CoV-2 [1:07:00];
Preparing for the possibility of a future pandemic and how we can learn from our mistakes [1:10:40]; and
More.

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Transcript

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0:00.0	Hey everyone, welcome to the Drive Podcast.
0:13.0	I'm your host, Peter Atia.
0:14.8	This podcast, my website, and my weekly newsletter, all focus on the goal of translating
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0:33.2	in depth content if you want to take your knowledge of this space to the next level.
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0:41.0	more now, head over to peteratiamd.com forward slash subscribe.
0:46.3	Now without further delay, here's today's episode.
0:49.0	I guess this week is Dr. Paul Offit.
0:53.1	That may be a familiar name to some of you because Paul was previously on the podcast
0:56.9	in November of last year.
0:58.9	At the time, we spoke about the COVID-19 vaccines just prior to their first approvals.
1:03.4	I want to have Paul back to get an update on the vaccines and to get a sense of what the
1:08.1	next year is going to look like.
1:10.2	As a refresher, Paul's a pediatrician specializing in infectious diseases and an expert on vaccines,
1:15.4	immunology, and virology.
1:17.4	He is the director of the Vaccine Education Center and professor of pediatrics in the
1:21.0	division of infectious diseases at the Children's Hospital of Philadelphia, CHOP.
1:25.2	And he is a professor of vaccineology at the Proman School of Medicine at the University
	...

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