#157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 12 April 2021

⏱️ 15 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

In this “Ask Me Anything” (AMA) episode, Peter and Bob take a deep dive into fat flux. They define the major players that impact the flow of fat entering and exiting a fat cell, which determines how much fat a person carries. They discuss the significant influence that insulin has on the net fat balance and explore common strategies, such as fasting and low-carb diets, that have efficacy in the liberation and oxidation of fat from fat cells. Additionally, Bob explains his research process and how he seeks answers to Peter’s challenging questions.

If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #22 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

The two main ways to reduce fat mass (1:30);
Explaining fat flux—how fat enters and exits a fat cell (9:15);
What fat balance looks like (21:15);
What net fat influx looks like, and the impact of insulin in lipolysis (24:30);
What net fat efflux looks like, and the benefits of fasting to break the hyperinsulinemic cycle (28:30);
Exploring why most people with excess body fat will lose fat mass when reducing carbohydrates or eating a ketogenic diet (32:45);
Why being in nutritional ketosis does not automatically translate to negative fat flux (fat loss) (42:40);
Bob’s approach to scientific research (47:00);
The importance of curiosity and a desire to learn (58:30);
Bob’s tips and tricks for answering a scientific question in a time-crunch (1:00:00); and
More.

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Transcript

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0:00.0	Hey everyone, welcome to a sneak peek, ask me anything, or AMA episode of the Drive Podcast.
0:16.5	I'm your host, Peter Atia.
0:18.3	At the end of this short episode, I'll explain how you can access the AMA episodes in full,
0:22.9	along with a ton of other membership benefits we've created.
0:25.9	Before you can learn more now by going to peteratia-md.com forward slash subscribe.
0:31.5	So without further delay, here's today's sneak peek of the Ask Me Anything episode.
0:39.4	Hey everyone, welcome to Ask Me Anything number 22, AMA number 22, and once again, joined
0:46.2	by Bob Kaplan.
0:47.2	In today's episode, we discuss Fat Flux, which is really technical speak for how fat enters
0:53.9	and exits a fat cell, which is exactly what determines how big a fat cell is, and how big
0:59.8	a fat cell is, is what determines how much fat a person is carrying.
1:03.4	So anytime you hear somebody say, I want to lose weight, what they're really saying is
1:07.5	I want to lose fat mass, and what that really means is I want my fat cells to be smaller.
1:13.3	So if you want to understand how that works, this is an episode that's probably for you.
1:18.4	Again, we go into it in a staggering amount of detail, this is accompanied by some slides.
1:24.7	So if you're watching this on video, you'll see those.
1:27.6	If not, you'll see them in the show notes.
1:29.1	I recommend checking that out.
1:30.6	Also, this video will be available in its entirety to the subscribers in the show notes
1:35.7	section.
1:36.7	If you're not a subscriber, but you still want to see part of the video, it's going to
1:39.3	be on YouTube on our YouTube channel.
	...

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