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Paul Saladino MD podcast

146. Does Red Meat Accelerate Aging, with David Sinclair PhD - UPDATE and REPOST

Paul Saladino MD podcast

Paul Saladino, MD

Medicine, Health & Fitness

4.82.7K Ratings

🗓️ 17 January 2022

⏱️ 136 minutes

🧾️ Download transcript

Summary

David Andrew Sinclair, PhD is an Australian biologist and professor of genetics. He is also a co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and is known for his research on aging with a focus on epigenetics.

Time Stamps:


0:35:27 Podcast begins with David Sinclair

0:36:25 Is when we eat more important than what we eat?

0:38:45 What is the connection between time restrictive eating and longevity?

0:43:54 What causes us to age?

0:45:46 Epigenetic change.

0:52:03 What causes DNA breaks?

0:55:28 What plant foods create DNA breaks?

0:57:13 PARP enzymes

1:00:46 Where does NAD come from? How do we make it? What enzymes use it?

1:04:50 NAD recycling pathway.

1:12:13 Sirtuins.

1:24:14 What are the other longevity genes? (AMP kinase and mTOR) How are they connected to sirtuins?

1:31:50 Does being in a ketogenic state increase NAD?

1:40:30 Xenohormesis and plant molecules.

1:45:50 Resveratrol trials.

1:51:55 mTOR.

1:57:25 David’s thoughts on animal protein.

2:04:03 Meat consumption in relation to the environment and regenerative agriculture.

2:11:28 Where to find David Sinclair.

David’s info:

https://genetics.med.harvard.edu/sinc...

https://lifespanbook.com/

Instagram: @davidsinclairphd

Twitter: @davidasinclair

Sponsors:

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Transcript

Click on a timestamp to play from that location

0:00.0

Perfect aid for intermittent fasting. Check out this review from John K on our fire starter supplement from heart and soil. I have used fire started daily for over one month and definitely plan on keeping it as part of my regimen.

0:14.0

I take this in the morning with quote bullet proof coffee and the fats keep me full all morning. I've lost some weight but more importantly, I don't feel starved and I still have energy and mental clarity to keep up with the middle schoolers I teach highly recommended how cool is that I love it. The fat and fire starter is high.

0:32.5

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0:46.5

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0:52.5

Okay, another awesome one. Check out this one pure cell regeneration. Collagen collagen collagen. This review is not just about the bone matrix. It's about the whole movement towards being radical and healthy to the next level.

1:06.5

At the age of 38 severe arthritis in my knees due to injury and sports or seating gums, colon problems, two months into bone matrix before again.

1:14.5

Fresh in the capsules when needed and gut and digestion. I can't remember what my knee pain is my GI tract is the happiest. It has been and my gums are coming back, which is phenomenal phenomenon.

1:29.5

I'm not sure if the matrix is a blessing, although I'm quite regimented with my bone broth. I don't always feel like going through 48 hour process. The supplement is absolutely necessary for my overall health. And it's the one I will always keep stocked on my shelf. Thanks Paul, you are radical show us your surfing videos soon.

1:46.5

This review is from Marco Marco you are radical Marco also appreciates gun and digestion and B for guns and they help his knees and his gut all kinds of good stuff. So in this series of reviews were highlighting fire starter B for guns, gun and digestion and bone matrix.

2:01.5

This is all a part of how you can reclaim your birth rights or radical health guys. This is what we do at heart and soil. We make grass fed grass finished freeze dried organs and capsules. It's amazing. Check us out heart and soil.

2:14.5

So in this week's podcast, I am commenting in the beginning on Davidson Claire's recent ideas that he talked about Andrew Hubertman's podcast. I'm good friends with Andrew as I mentioned his podcast.

2:26.5

And hopefully Andrew and I will get a chance to talk on his podcast and mine about how my ideas different than Davis, different than David. However, I also had David on my podcast in 2019 and we talked about cellular regeneration, longevity aging DNA damage and MN and a D.

2:41.5

But this is a good time to repost that conversation because many of you may not have heard or may have missed the 2019 conversation I did with Davidson Claire.

2:50.5

It's quite technical as many of you know David is amazing is a PhD from Harvard Medical School and has done a lot of research into molecules, resvera, troll among others. And there are times at the end of this podcast that David and I get to have a little bit of friendly debate. I'd love to have David back on the show for more in depth friendly debate to share our different opinions.

3:06.5

And right now I felt like this is the best way to discuss this in the beginning of the podcast, I give about 20 minutes of my book ended perceptions, our discussions, my opinions on that my views have changed since 2019.

3:19.5

And then I will repost the 2019 podcast with David and Claire, which I think many of you guys will find very educational and enjoyable. So enjoy this one with Davidson Claire. My thoughts on Davidson Claire and hopefully we'll do another one David and I will because David's great guy.

3:35.5

And I know we disagree with always been able to discuss these things with a jovial friendly manner.

3:40.5

This podcast is free. Thank you for your support of it. Thanks for leaving me a review on Apple podcast that is really one of the best ways to move the needle and help so many more people here this podcast.

3:51.5

Thank you for a thank you as a thank you to those who leave a review on Apple podcasts that will give away a free sign copy my book every month, the one person who does that. So thank you for that.

3:59.5

And also thank you to my sponsors, they make this free podcast possible. I got to give a shout out to the folks at white oak pastures white oak pastures.com.

4:08.5

They are making grass fed grass finished regeneratively maves raised beef organs chicken turkey guinea. They have soy and corn free chicken soy and corn free eggs amazing. They're doing a great job of feeding so many of their animals in a species appropriate way in bluffed in Georgia.

4:22.5

Jen and her and Jen and Jen and Jenny Harris and will Harris are amazing people and I so appreciate their work they're doing you can find them white oak pastures.com use the code carnivore and D for 10% off your first order.

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