meta_pixel
Tapesearch Logo
Log in
Lex Fridman Podcast

#142 – Manolis Kellis: Meaning of Life, the Universe, and Everything

Lex Fridman Podcast

Lex Fridman

Technology, Society & Culture, Philosophy, Science

4.713.6K Ratings

🗓️ 30 November 2020

⏱️ 136 minutes

🧾️ Download transcript

Summary

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:
Grammarly: https://grammarly.com/lex to get 20% off premium
Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil
Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast
Apple Podcasts: https://apple.co/2lwqZIr
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
YouTube Full Episodes: https://youtube.com/lexfridman
YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:
– Check out the sponsors above, it’s the best way to support this podcast
– Support on Patreon: https://www.patreon.com/lexfridman
– Twitter: https://twitter.com/lexfridman
– Instagram: https://www.instagram.com/lexfridman
– LinkedIn: https://www.linkedin.com/in/lexfridman
– Facebook: https://www.facebook.com/LexFridmanPage
– Medium: https://medium.com/@lexfridman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(06:48) – Music and life
(46:21) – The number 42
(52:22) – The question about the meaning of life
(55:02) – Are humans unique in the universe?
(1:00:46) – Human civilization
(1:12:52) – Mars
(1:14:45) – Human mind and the abstraction layers of reality
(1:25:38) – Neural networks and intelligence
(1:32:55) – Ideas as organisms
(1:42:19) – Language
(1:53:34) – Legacy
(2:08:25) – Poems

SONGS MENTIONED:
[1] Dwros Gewrgiadis – An imoun plousios
https://www.youtube.com/watch?v=7akZoEQv6jI
[2] Grigoris Bithikotsis – Ftoxologia
https://www.youtube.com/watch?v=TyGR24O0KQ8
[3] Sto perigiali to kryfo
https://www.youtube.com/watch?v=B-GBPx_GXQw
[4] Michael Jackson – Man in the Mirror
https://www.youtube.com/watch?v=Zqe5NP86OCc
[5] George Michael – Careless Whisper
https://www.youtube.com/watch?v=izGwDsrQ1eQ
[6] Gainsbourg with Isabelle Adjani – Pull Marine
https://www.youtube.com/watch?v=o7MwHGHWgLk
[7] Georges Moustaki – Le meteque
https://www.youtube.com/watch?v=MV8fGf-N06A
[8] Jacques Brel – Ne me quitte pas
https://www.youtube.com/watch?v=q_bq5mStroM
[9] Sting – Englishman In New York
https://www.youtube.com/watch?v=d27gTrPPAyk
[10] Sting – Fragile
https://www.youtube.com/watch?v=lB6a-iD6ZOY
[11] Pink Floyd – The Wall (When the Tigers Broke Free)
https://www.youtube.com/watch?v=l9b9UhFe6Eg
[12] Pink Floyd – The Wall (One Of My Turns)
https://www.youtube.com/watch?v=BOay-7aqLks
[13] Sting – Russians
https://www.youtube.com/watch?v=wHylQRVN2Qs
[14] Joni Mitchell – Both sides now
https://www.youtube.com/watch?v=aCnf46boC3I
[15] Leonard Cohen – I’m Your Man
https://www.youtube.com/watch?v=yOnXe8ttmjY
[16] Alison Krauss & Union Station – The Lucky One
https://www.youtube.com/watch?v=jcRZ_J_VgNc

Transcript

Click on a timestamp to play from that location

0:00.0

The following is a conversation with Manolis Kellis, his fourth time on the podcast.

0:04.8

He's a professor at MIT and head of the MIT Computational Biology Group.

0:10.4

Since this is episode number 142 and 42, as we all know, is the answer to the ultimate

0:17.9

question of life, the universe, and everything according to the hitchhiker's guide to the galaxy.

0:23.5

We decided to talk about this unanswerable question of the meaning of life.

0:28.0

In whatever way we two descendants of apes could muster from biology, psychology,

0:34.0

to metaphysics, and to music.

0:37.5

Quick mention of each sponsor followed by some thoughts related to the episode.

0:42.0

Thanks to Grammarly, which is a service for checking, spelling, grammar,

0:47.3

sentence structure, and readability, athletic greens, the all-in-one drink that I start every day

0:53.6

with to cover all my nutritional bases and cash app. The app I use is at my need of friends.

1:00.2

Please check out these sponsors in the description to get discount and to support this podcast.

1:05.5

As a side note, let me say that the opening 40 minutes of the conversation are all about the

1:10.6

many songs that formed the soundtrack to the journey of Manolis' life. It was a happy accident

1:16.9

for me to discover yet another dimension of depth to the fascinating mind of Manolis.

1:22.0

I include links to YouTube versions of many of the songs we mentioned in the description

1:27.3

and overlay lyrics on occasion. But if you're just listening to this without listening to the songs

1:33.0

or watching the video, I hope you still might enjoy as I did the passion that Manolis has for music.

1:39.0

His singing of the little excerpts from the songs and in general the meaning we discuss

1:45.5

that we pull from the different songs. If music is not your thing, I do give timestamps

1:51.8

to the less musical and more philosophical parts of the conversation. I hope you enjoy this

1:58.0

little experimenting conversation about music and life. If you do, please subscribe by YouTube,

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from Lex Fridman, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Lex Fridman and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2026.