#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 17 August 2020

⏱️ 17 minutes

🔗️ Recording | iTunes | RSS

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Summary

As a follow up to AMA #14 where Peter explained his framework for analyzing labs, this “Ask Me Anything” (AMA) episode focuses on a number of real-world case studies exploring metabolic dysregulation, low testosterone, menopause, hypothyroidism, elevated uric acid, and more. From the examples discussed, you can follow along how our clinical team goes about interpreting diagnostic measures and applying relevant research findings. Once again, Bob Kaplan, Peter’s head of research, will be asking the questions. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #15 show notes page.

We discuss:

Should you stop taking supplements before getting a lab test? [2:45];
Family history—Questions to ask and what to look for [5:30];
The purpose of an oral glucose tolerance test (OGTT) [12:15];
Case study—Insufficient muscle mass for proper glucose disposal [17:15];
Why hemoglobin A1c is a relatively unhelpful metric [24:00];
Case study—Exceeding carbohydrate tolerance [26:30];
Case study—Metabolic dysfunction and a framework for metabolic health [33:30];
Peter’s ideal tracking of metabolic health for all his patients [43:30];
Contrasting presentations of hypogonadism—Low free testosterone [45:00];
How sleep, exercise, and alcohol affect testosterone levels? [56:20];
Case study—Surprisingly fast onset of menopause [59:25];
Case study—Hypothyroidism and high cholesterol [1:07:00];
Case study—Elevated uric acid and hypertension [1:10:55]; and
More.

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Show notes page for this episode: https://peterattiamd.com/ama15

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Transcript

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0:00.0	Hey everyone, welcome to a sneak peek, ask me anything, or AMA episode of the Drive Podcast.
0:16.5	I'm your host, Peter Atia.
0:18.3	At the end of this short episode, I'll explain how you can access the AMA episodes in full,
0:22.9	along with a ton of other membership benefits we've created.
0:25.9	Before you can learn more now by going to peteratia-md.com forward slash subscribe.
0:31.5	So without further delay, here's today's sneak peek of the Ask Me Anything episode.
0:36.5	Welcome to Ask Me Anything, or AMA episode number 15.
0:45.6	In May, we released the first part of our AMA focusing on my framework for analyzing labs.
0:51.6	In that episode, it took me a little longer to get to some of the actual labs, and we weren't
0:55.4	able to cover as much as I wanted.
0:56.9	So this is a follow-up to that greatly appreciated episode.
1:00.6	People had a lot of really kind things to say about it.
1:02.7	They really wanted more.
1:04.4	And so it was a pretty easy decision to follow up and go a lot deeper.
1:08.6	Because in that episode, we really only got to cardiovascular labs.
1:11.4	In this episode, we kick it off with some of this stuff around insulin sensitivity, getting
1:16.3	into some oral glucose tolerance tests.
1:19.2	We get into testosterone replacement.
1:22.4	We talk about menopause and female sex hormones, thyroid hormone, other metabolic stuff that
1:29.3	can be gleaned from labs.
1:31.1	Overall, I found this to be a really fun episode, and I'm really glad we did it.
1:34.4	And also, there are a couple other pretty cool nuggets that cappeln through in here based
	...

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