#108 - AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 21 April 2020

⏱️ 16 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

In this “Ask Me Anything” (AMA) episode, Peter explains some observations he’s noticed since switching to a 3-day fasting cycle from the longer fasts, the various things he’s measuring, and some helpful tips for getting through a prolonged fast. He also discusses the role of exogenous ketones in fasting and ketogenic diets as well as their impact on autophagy, specifically. Finally, Peter provides some practical advice for those looking to fit exercise for longevity into their busy life. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA.

If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #13 show notes page. If you are not a subscriber, you'll be able to listen to a sneak peak of this episode.

We discuss:

Peter’s observations since switching from a 7-day to a 3-day fasting regimen [1:25];
Ketone measuring devices—blood and breath [7:40];
Can zero-calorie sweeteners affect ketone production? [10:40];
Will there be a continuous insulin monitor anytime soon? [11:55];
Exogenous ketones—Role in fasting and ketogenic diets and their effect on insulin, blood glucose, and autophagy [14:10];
5 tips to help you get through a multi-day fast [25:55];
Relationship between BHB levels, glucose levels, and autophagy—Are high levels of ketones enough to produce autophagy? [34:10];
Why is measuring blood insulin so much harder than blood glucose? [36:55];
Advice and resources for people wanting to stay up to date on developments related to health and longevity (and how to quickly sift through all the bad science) [40:10];
Advice for those looking to fit exercise for longevity into their busy life [51:10]; and
More.

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Show notes page for this episode: https://peterattiamd.com/ama13

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Transcript

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0:00.0	Hey everyone, welcome to a sneak peek, ask me anything, or AMA episode of the Drive Podcast.
0:16.5	I'm your host, Peter Atia.
0:18.3	At the end of this short episode, I'll explain how you can access the AMA episodes in full,
0:22.9	along with a ton of other membership benefits we've created.
0:25.9	Before you can learn more now by going to peteratia-md.com forward slash subscribe.
0:31.5	So without further delay, here's today's sneak peek of the Ask Me Anything episode.
0:39.8	Welcome to another edition of Ask Me Anything, AMA episode 13.
0:43.8	I'm joined again today by my head research pod, Kaplan.
0:47.2	In this episode, we talk about a bunch of things.
0:50.5	It was supposed to be rapid fire, but we, on the first question, got so far off the rails,
0:56.0	and I think it literally took up half the time.
0:58.0	But it was basically a question about seven day versus three day water fasts, and then
1:02.6	that evolved, or devolved, depending on how you think of it, into all things related
1:07.9	to fasting, how you cope with them, all the things that you would measure, what's happening
1:12.0	physiologically, the use of exogenous ketones, etc.
1:15.8	We then pivoted off to some other topics, such as favorite resources that I have for
1:22.1	staying up to date on information as it relates to medicine, health longevity.
1:27.3	We talked a little bit about exercise, and specifically how one might craft an exercise
1:32.3	program around longevity.
1:34.3	I hope you enjoy this episode of AMA 13.
1:38.3	Hey everyone, welcome to another Ask Me Anything, or AMA with Peter Atia.
1:49.6	Peter, how you doing?
	...

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