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The Matt Walker Podcast

#101 - The Sleep Prescription To Better Immunity with Dr. Aric Prather

The Matt Walker Podcast

Dr. Matt Walker

Medicine, Science, Social Sciences, Health & Fitness

4.8995 Ratings

🗓️ 7 July 2025

⏱️ 55 minutes

🧾️ Download transcript

Summary

Matt welcomes UCSF sleep expert Dr. Aric Prather to the podcast this week to discuss the science of psychoneuroimmunology: the link between our behavior and immune health. After a primer on the immune system’s innate and adaptive arms, Dr. Prather details how insufficient sleep dramatically increases your risk of catching a cold, significantly blunts vaccine effectiveness by reducing antibody response, and promotes a state of chronic, low-grade inflammation - a known pathway to numerous age-r...

Transcript

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0:00.0

Hi there, it's Matt here and welcome back to the show and welcome back to another of the guest

0:08.5

episodes. My guest today is the fantastic Eric Prather. Eric, a PhD, wonderful guy. He is a leading

0:19.0

expert in sleep science and behavioral health. He is serving as

0:24.5

professor of psychiatry and behavioral sciences at the University of California, San Francisco,

0:31.4

just across the bay from me here at the University of California, Berkeley. He is the director

0:36.7

of the UCSF Center for Health and Community,

0:40.8

and he co-directs the UCSF, aging, metabolism, and emotion center.

0:47.8

His research has, in my mind, it's significantly advanced our understanding of how sleep impacts physical health,

0:56.7

immunity, as well as emotional well-being, meaning that he's just one of those people who

1:03.3

has plurality. He just seems to be able to annoyingly do everything.

1:07.7

Eric's work, it's frequently featured in high-impact journals and media outlets like

1:13.1

The New York Times and NPR. I should also note, by the way, he's written a fantastic book.

1:19.8

His fantastic new book, The Sleep Prescription, Seven Days to Unlocking Your Best Rest. You absolutely need to go out and check it out. It's a

1:30.1

wonderfully informative, elegantly written in terms of digestible bite-sized chunks, seven-day guide,

1:38.1

and not just seven-day guide, but from morning to evening on each one of those days guide.

1:45.9

And he has just an exceptional ability to translate complex science into actionable strategies. It's not just that you understand

1:51.0

the science, you understand what to do with it. And I think his insights have really reshaped

1:55.8

how we view and manage sleep health in both clinical and everyday settings.

2:01.8

So without further ado, Eric, welcome to the show.

2:05.4

And I'll first ask you maybe just give some background in addition to that.

2:10.6

And don't be shy.

2:11.5

Don't be modest as to what you do, but also just how did you get into sleep science? Yeah, thank you for having me.

...

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