10 New Oxidative Stress & Gut Health Biomarkers to Know
The Root Cause Medicine Podcast
Kate Kresge
4.8 • 581 Ratings
🗓️ 25 July 2025
⏱️ 58 minutes
🔗️ Recording | iTunes | RSS
🧾️ Download transcript
Summary
In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge welcomes back Dr. Cheryl Burdette—naturopathic physician, educator, and founder of Precision Point Diagnostics—for a deep dive into one of the most evidence-backed biomarker bundles in functional medicine: the Gut, Oxidation & Stress panel. Dr. Burdette explains how ten underutilized but highly predictive biomarkers—including anti-LPS antibodies, zonulin, 8OHdG, F2-isoprostanes, glutathione, and more—can give clinicians a full-body snapshot of inflammation, leaky gut, immune dysregulation, and oxidative stress. She discusses how each marker ties into chronic conditions from cardiovascular disease to autoimmunity to neuroinflammation—and exactly how to intervene when these labs are out of range. This is a must-listen masterclass for any practitioner working with chronic illness, mystery symptoms, or “normal” labs that don’t tell the whole story. You’ll Hear Them Discuss: - Why LPS antibodies are one of the most predictive markers in medicine today - How oxidative stress contributes to cardiovascular disease, autoimmunity, and brain fog - What 8OHdG, zonulin, secretory IgA, and glutathione tell us about barrier integrity - The surprising links between gut dysfunction and GLP-1, mood, and immune balance - Case studies showing biomarker-guided interventions that worked - How to boost glutathione (and what forms work best) - When to re-test and what lab shifts to look for - Advanced testing for food sensitivity: IgG subclasses, complement, and tolerance vs. reactivity - Natural GLP-1 agonists, bitters, fiber, and bile as part of metabolic healing
Transcript
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| 0:00.0 | Well, hello there and welcome to the root cause medicine podcast. I'm your host for today, Dr. Kate Kreske, and we are sitting down with the incredible Dr. Cheryl Burdette. Dr. Cheryl is an instructor for us at Ruby University. She's teaching a course that starts next week called Food Sensitivities, Gut Health and Detoxification, a functional medicine approach. Now, something new that she's teaching you about in this course are 10 novel stress |
| 0:22.9 | and oxidation markers, things like F2 isoprostines, 8, OHDG, total glutathione, anti-zonialin |
| 0:29.9 | antibodies, anti-lps antibodies, secretary IGA, you name it, she's going to talk about it today, |
| 0:35.9 | and why you might want to consider screening your clients for it. The bottom line, we now have the ability to simultaneously |
| 0:41.3 | quantify intestal permeability, microbial translocation, and systemic oxidative damage, |
| 0:46.6 | using just the patient's mail-in results. Dr. Bredat walks us through the evidence behind |
| 0:51.0 | why we should be testing these biomarkers regularly in folks who show up with |
| 0:54.6 | gut issues and chronic illnesses and what to do if they're elevated or abnormal. Before we get |
| 0:59.9 | started, though, I've got a special question for the healthcare providers in the audience. What if |
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| 1:39.0 | In a recent survey, 74% of providers reported saving up to three hours per week using FulScript to create treatment |
| 1:45.5 | plans. |
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| 1:49.1 | Visit FulScript.com to get started today. |
| 1:52.1 | And one last important note. |
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