10-Minute Weekly Update : 1335
The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 26 September 2025
⏱️ 11 minutes
🧾️ Download transcript
Summary
Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts.
This episode covers:
- Rapamycin’s Reality Check:
A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adults is still weak and inconsistent. Dave shares why lifestyle levers (fasting, protein timing, smart training) come first, and any rapamycin experiment should be clinician-guided and tracked with labs.
Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025
- Senolytics Get Precise:
New research (September 23) shows that not all “zombie cells” (senescent cells) are equal in how they respond to anti-aging drugs—so future protocols will be timed and typed, not one-size-fits-all.
Source: Aging-US research stream – September 23, 2025
- AI Healthcare: Promise and Pause:
The latest market outlook (September 23) says AI in healthcare is surging toward a $100B+ market by 2030, but 70% of doctors still want humans in the loop for diagnosis. Dave shares how to use AI as your copilot—not your captain.
Source: Crescendo.ai – September 23, 2025
- Medical Policy Meets Machine Logic:
A new federal pilot now lets AI approve or deny Medicare coverage, possibly cutting off therapies before a human review happens. Dave explains how to demand explainability, fair appeals, and human override to protect access.
Source: KFF Health News policy rundown – September 25, 2025
- Longevity Headlines You Can Use:
- Forest bathing wins renewed praise for helping with blood pressure and stress.
- Northwestern’s SuperAger project links strong social ties to resilient brain health.
- Human trials now test an antibody therapy to regrow lost teeth.
Source: XandroLab Longevity Roundup – Week of Sept 22–25, 2025
Action steps for the week:
- Try fasting windows and smart protein clustering for mTOR modulation.
- Let AI help summarize your health data—but get decisions confirmed by your clinician.
- If you or your family touch Medicare, keep thorough documentation and demand human review.
- Soak in green spaces, reconnect socially, and watch for cutting-edge therapies.
All source links provided for easy reference to the original reporting and research above.
This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Rapamycin, mTOR modulation, longevity, biohacking, senolytics, zombie cells, AI healthcare, Medicare coverage, human trials, forest bathing, SuperAger, brain health, fasting, protein cycling, medical freedom, anti-aging, personalized medicine, health tech, Dave Asprey, Human Upgrade podcast
Thank you to our sponsors!
- LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.
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Resources:
• Danger Coffee: https://dangercoffee.com/discount/dave15
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen: https://40yearsofzen.com
Timestamps:
0:00 — Intro
0:18 — Rapamycin Hype Check
1:07 — Senolytics Leveled Up
2:41 — AI in Healthcare
3:11 — AI Between You and Your Doctor
5:50 — Three Longevity Angles
7:59 — Outro
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Transcript
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| 0:00.0 | I'm Dave Asprey. That's Dave spelled D-A-I-V-E. And this is your 10-minute weekly upgrade on the biggest stories in biohacking, longevity, and the world of health. Let's go. |
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| 1:03.4 | code Dave-10. |
| 1:19.6 | Story 1. Rapamycin Hypecheck. A major review from Agingus.com on September 24th is calling out the gap between animal wins and human reality. Translation, in healthy adults, clinical evidence for lifespan or |
| 1:26.7 | true aging reversal just isn't there yet. |
| 1:30.0 | And safety flags mean we need longer, better trials before people pop it off label like a vitamin. |
| 1:36.3 | I've said this before. |
| 1:38.8 | MTOR is powerful. |
| 1:40.3 | Rapamycin is interesting. |
| 1:42.9 | But lifestyle levers hit the same pathway with fewer unknowns. |
| 1:47.4 | Fasting, protein timing, intelligent training, use data guys, not dogma. |
| 1:54.7 | Story 2. |
| 1:55.7 | Cenilletics just leveled up. |
| 1:58.0 | On September 23rd, new data showed why results have been all over the map. |
| 2:02.6 | Cinescent cells aren't one thing. They're a zoo, and their kill switches change with cell cycle |
... |
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