088 - Powerful Peptides: CGRP and the Paradigm Shift in Migraine Prevention
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
Sean P. Kane, PharmD, BCPS
5 • 644 Ratings
🗓️ 11 December 2018
⏱️ 39 minutes
🧾️ Download transcript
Summary
In this episode, we will discuss a new class of medications for preventing migraines called CGRP antagonists, including an overview of their development, clinical efficacy, and future goals of further research in this area.
Transcript
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| 0:00.0 | Welcome to Helix Talk, an educational podcast for healthcare students and providers covering real-life clinical pearls, professional pharmacy topics, and drug therapy discussions. |
| 0:11.0 | This podcast is provided by pharmacists and faculty members at Rosal Franklin University College of Pharmacy. |
| 0:17.0 | This podcast contains general information for educational purposes only. This is not professional |
| 0:22.5 | advice and should not be used in lieu of obtaining advice from a qualified health care provider. |
| 0:27.2 | And now on to the show. |
| 0:31.1 | Welcome to Helix Talk 88. I'm your co-host, Dr. Kane. I'm Dr. Schumann. I'm Dr. Patel. |
| 0:36.8 | And today I'd actually like to introduce a guest speaker with us today, Dr. Kane. I'm Dr. Schumann. I'm Dr. Patel. And today I'd actually like to introduce a guest |
| 0:39.5 | speaker with us today. Dr. Eileen Mintz is our current PGI2 resident at a level federal |
| 0:45.6 | health care center, hailing from Northeast where she did her PGY1 at Kingsbrook and is again |
| 0:51.8 | excited to come by with us and talk about our topic about migrains or |
| 0:55.6 | powerful peptides, CGRP, and the paradigm shift in migraine prevention. Glad to have you, |
| 1:00.7 | Dr. Mintz. Thank you for having me. I'm excited to be here. So Dr. Schumumumum, when you first |
| 1:07.1 | brought up this topic, I'd actually never even heard of this drug category, and it sounds like this could be something groundbreaking in the future that listeners, |
| 1:15.1 | whether it be pharmacists or other healthcare professionals, are likely to be encountering |
| 1:19.3 | this new drug class in the near future. |
| 1:21.0 | Is that correct? |
| 1:21.6 | Yeah, so it's funny because people say, oh, it'd say it's a new thing, a new target. |
| 1:25.5 | Well, technically, it's not as new. First of all, back in episode 64, we talked about stimulation of the trigeminal nerve, |
| 1:32.3 | and that leads to vasodilation and pain as this pathophysiology of a migraine headache, |
| 1:37.6 | and so we've got the role for serotonin. |
| 1:39.7 | We already know that part, and that's why we look at these tryptans as the serotonin 5HT 1BD agonist |
| 1:46.2 | and those medications have been used for years as a way of blocking the signaling pathways |
... |
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