#085 Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging

FoundMyFitness

Rhonda Patrick, Ph.D.

Fitness, Depression, Foundmyfitness, Timferriss, Sleep, Diet, Longevity, Ketosis, Rhondapatrick, Kevinrose, Domdagostino, Health, Sauna, Nutrition, Medicine, Fasting, Healthspan, Mattwalker, Coldexposure, Lifeextension, Health & Fitness, Exercise

4.8 • 5.5K Ratings

🗓️ 27 December 2023

⏱️ 239 minutes

🔗️ Recording | iTunes | RSS

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Summary

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Peter Attia, MD is a highly respected expert in preventive medicine, focused on the crucial subject of longevity and cardiovascular health. He's also the author of the NY Times best selling book Outlive - which I highly recommend if you have not read it already. Peter's philosophy transcends the conventional goal of merely extending lifespan; it's about enriching the quality of every year, ensuring that each stage of life is lived with optimal health and vitality.

In this episode, we discuss:

(00:07:36) Defining cardiovascular disease
(00:09:43) Coronary plaque and fatality risk
(00:11:09) What is cholesterol?
(00:13:34) How ApoB predicts heart disease
(00:21:34) Factors elevating ApoB
(00:25:24) ApoB reference range explained
(00:27:23) Does high ApoB cause cardiovascular disease
(00:37:01) ApoB thresholds for ASCVD prevention
(00:40:27) Dietary factors raising ApoB
(00:39:33) Genetics of ApoB and LDL
(00:53:24) Does low LDL increase cancer?
(00:56:19) Cholesterol-lowering drugs
(00:59:59) Statins, uses, and side effects
(01:03:12) Are statins toxic to mitochondria?
(01:09:56) Ubiquinol for statin-induced muscle soreness
(01:11:09) How to train in zone 2
(01:17:09) Statins and neurodegenerative disease risk
(01:21:54) Cholesterol synthesis in the brain (desmosterol role)
(01:25:58) Statin alternatives – pros and cons
(01:27:30) Ezetimibe
(01:31:01) Bempedoic acid
(01:36:49) Berberine for CVD Risk Reduction?
(01:39:36) Muscle as a glucose sink
(01:45:58) Chronic glucose toxicity and vascular impact
(01:51:38) Hemoglobin A1C Levels and Mortality Data
(01:55:35) 80/20 Zone 2/VO2 Max Training Protocol
(02:02:12) Insights from VO2 max testing data
(02:12:17) How obesity increases cancer risk
(02:15:03) Cancer screening benefits and risks
(02:20:47) Dr. Attia's recommended cancer screening age
(02:28:54) Liquid biopsies for detecting cancer
(02:34:48) CT scans, mammograms and radiation concerns
(02:40:32) Menopause – hormonal shifts and health effects
(02:45:13) Hormone replacement therapy (HRT)
(02:58:57) Perimenopause diagnosis with hormone levels
(03:02:04) HRT's impact on dementia, cancer, and heart disease risk
(03:04:49) Estrogen's role in bone density
(03:07:42) Vitamin D
(03:16:24) Testosterone replacement for women's sexual function
(03:18:47) HRT safety 10 years post-menopause
(03:23:05) Treating low testosterone in men
(03:29:53) TRT side effects and risks
(03:32:33) Ways to reduce blood pressure
(03:39:33) How to measure blood pressure
(03:45:30) Peter's longevity optimization routines

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Transcript

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0:00.0	Welcome to the Found My Fitness Podcast. I'm your host, Rhonda Patrick. Today's episode features Dr Peter Attia.
0:06.6	Dr Peter Attia is a highly respected expert in preventative medicine with a special focus on applied science of longevity.
0:13.0	His deep engagement with the topic of longevity is the cornerstone of his New York Times best selling book, Outlive,
0:19.0	the science and art of longevity.
0:21.0	Dr. Attia also extends his expertise into his clinical
0:24.3	practice early medical and shares his knowledge through his popular podcast many of
0:28.9	you are already aware of the drive. In this episode you will learn why Apo B is a superior predictor of
0:35.0	cardiovascular disease over LDL particle number and managing the four main factors
0:40.5	that elevate Apo B. Why apo B exist in humans when it doesn't in most species.
0:47.0	Whether or not low-LDL is a risk factor for cancer and a variety of other surprising facts about LDL biology you really can't find anywhere else.
0:57.0	Peter's opinion on Apo B reference ranges.
1:00.0	Whether there is an Apo B level low enough that it is impossible to die from atherosclerosis.
1:07.0	Which dietary factors increase apo B?
1:10.0	How statins and other lipid lowering pharmacotherapies work, including their side effects and costs,
1:16.8	and what the alternatives are, the pros and cons of different statin alternatives,
1:22.3	how increased muscle mass helps achieve lower blood
1:25.4	sugar levels, which may play a pivotal role in reducing overall mortality, and the potential
1:31.3	for glycemic control to be suboptimal well before doctors identify it.
1:36.5	Peter's 80% zone 2, 20% V.O.2. Max training protocol.
1:41.8	The dangers of visceral fat and why it correlates with increased cancer risk.
1:46.3	Peter outlines the benefits and risks of aggressive cancer screening and offers insights on
1:51.6	optimal screening timing.
	...

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