#075 Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder
FoundMyFitness
Rhonda Patrick, Ph.D.
4.8 • 5.5K Ratings
🗓️ 31 May 2022
⏱️ 58 minutes
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Summary
The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators.
Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease.
Show notes and video
CHAPTERS:
06:04 - Introduction
08:12 - Atherosclerosis
13:49 - Brain
16:07 - Circulating LPS and behavior
19:05 - Toll-like receptors and inflammation
24:00 - Factors that affect intestinal permeability
30:10 - Alcohol
32:07 - Gluten
35:21 - Butyrate and dietary fiber
37:48 - Dietary fat
42:21 - Biomarkers of intestinal permeability
43:11 - Omega-3 fatty acids
50:02 - Q&A
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Learn about the blood-brain barrier
Learn about intestinal permeability
Learn about toll-like receptors
Learn about cerebral small vessel disease
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Transcript
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| 0:00.0 | Hi friends, I recently had the privilege of delivering a keynote address at the Metabolic |
| 0:04.5 | Health Summit held in early May in Santa Barbara. |
| 0:07.5 | The particular circumstance for this presentation came about directly as a result of Dr. Dominic |
| 0:12.1 | Dagestino's invitation, one of the events organizers and my most recent podcast guest. |
| 0:17.9 | Anyone who has heard my recent episode with DOM will know exactly why this presented |
| 0:21.8 | a unique challenge. |
| 0:23.9 | Keynoting for a Metabolic Health conference, especially when organized by DOM, forced me |
| 0:28.1 | to really reflect on what I could best bring to the event that might be special or unique, |
| 0:32.7 | but still ultimately speak to the theme of the conference, metabolism. |
| 0:37.1 | My resulting presentation describes how intestinal permeability and bacterial products play |
| 0:42.3 | into chronic disease, inflammation, and through inflammation aging. |
| 0:47.5 | In this presentation, I talk about how intestinal permeability promotes the release of bacterial |
| 0:52.3 | products from the gut into the bloodstream and how this stimulates the immune response |
| 0:56.7 | sometimes chronically. |
| 0:58.9 | It's thought that we all have some degree of post-prondial inflammation, partly as a response |
| 1:04.1 | of that mechanism, but how that plays out may depend on our individual gut integrity, |
| 1:09.1 | as well as the responsiveness, or sometimes hyper-responsiveness of our individual immune |
| 1:13.9 | systems. |
| 1:16.1 | Inflammation isn't the only factor, though it's an important one. |
| 1:19.0 | The bacterial product, Leipopoli Saccharide, also interacts directly with LDL particles |
| 1:24.2 | in a deleterious way, which makes up a second and even more direct mechanism that may |
| 1:29.4 | promote atherosclerosis. |
... |
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