Welcome to Helix Talk, an educational podcast for healthcare students and providers covering real-life clinical pearls, professional pharmacy topics, and drug therapy discussions.

This podcast is provided by pharmacists and faculty members at Roslyn Franklin University College of Pharmacy.

This podcast contains general information for educational purposes only. This is not

professional advice and should not be used in lieu of obtaining advice from a qualified health

care provider. And now on to the show. Welcome to Helix Talk episode 53. I'm your co-host

Dr. King. I'm Dr. Schumann. And I'm Dr. Patel. Today we're continuing on with our previous topic on drug interactions with the topic of

drug mixology and dangerous consequences part two.

And with that being said, let's dive right into one of the popular questions we get from

not only student pharmacists but patients you know what

to do with the beloved grapefruit or grapefruit juice can I drink it or not and so

that being said most commonly the issue that we see is grapefruit juice is

known to cause inhibition of one of the sipIP enzyme that SIP 3A4 in the small

intestine.

And this can lead to reduction in the first past metabolism, which what it means, it basically

increases the concentration of some of the drugs that go through or metabolize using

the SIP 3A4 enzyme.

So examples of these drugs are certain statins, as we discussed in the previous episode, amiodarone

and certain calcium channel blockers such as I'm low to pain, nipatopathy, and the antitra

and the transplant agents such as cyclosporine.

So Dr. Patel, what you're saying is if I drink grapefruit juice with my statin, my statin

will work a lot better.

Potentially, it would work a lot better.

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