#05 - Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 16 July 2018

⏱️ 163 minutes

🔗️ Recording | iTunes | RSS

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Summary

Dom digs deep into the research and application of ketogenic diets, exogenous ketones, hyperbaric oxygen treatment, and treating cancer with a metabolic approach. Plus, we lost track of the number of n=Dom experiments mentioned in this episode.

We discuss:

Dom’s early medical training in hyperbaric chambers [7:00];
Effect of ketones on cancer cells [20:00];
Ketones and oxygen toxicity seizures [32:00];
HBOT & its many applications [40:00];
Ketones, MCTs, and exogenous ketones [59:15];
How ketones affect blood glucose [1:20:00];
Ketone esters, salts, enantiomers vs. racemic BOHB [1:38:00];
Dom’s ketone tolerance test [1:56:00];
The metabolic management of cancer with a Press-Pulse approach [1:59:45]; and
More.

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Transcript

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0:00.0	Hey everyone, welcome to the Peter Atia Drive. I'm your host, Peter Atia.
0:10.0	The drive is a result of my hunger for optimizing performance, health, longevity, critical thinking,
0:15.7	along with a few other obsessions I've gathered along the way.
0:18.6	I've spent the last several years working with some of the most successful top performing
0:21.9	individuals in the world, and this podcast is my attempt to synthesize what I've learned
0:26.1	along the way to help you live a higher quality, more fulfilling life.
0:30.2	If you enjoy this podcast, you can find more information on today's episode and other
0:34.1	topics at PeterAtiaMD.com.
0:36.4	In this episode, I interview my good friend Dominic Dagostino.
0:46.6	Dom, as he is known by his professor at the University of South Florida.
0:52.0	His PhD is in neuroscience, and that's where he got his background.
0:56.2	Dom is probably most recognizable to people listening to this because he is certainly
1:00.2	one of the experts on ketosis.
1:03.7	That's in all variants of it.
1:05.0	So, starvation ketosis, nutritional ketosis, and in particular, the use of exogenous ketones.
1:10.8	Gosh, Dom and I go way back.
1:12.6	We met probably a little over five years ago and instantly formed a friendship around
1:17.2	our obsessive end of one experiments.
1:20.0	So I will say he is closer to winning a Darwin Award on the basis of his end of ones than
1:26.0	I am.
1:27.4	Couple notes about this podcast.
1:28.8	First, this is highly technical at times.
	...

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